The Effects of Anesthesia and Surgery on Count and Function of Neutrophils

Overview

Journal J Anesth

Specialty Anesthesiology

Date 1989 Sep 1

PMID 15236027

Citations 9

Authors

Y Tabuchi

S Shinka

H Ishida

Affiliations

Soon will be listed here.

Abstract

The effects of anesthesia and surgery on neutrophil count, chemotaxis and neutrophil alkaline phosphatase (NAP) score were investigated in 10 patients who had elective spine surgery. Plasma levels of adrenaline, noradrenaline and cortisol were measured and correlations between hormonal levels and neutrophil count and function were assessed. Neutrophil count started increasing after the initiation of surgery, reached the highest level at 3 hours after surgery, and decreased gradually toward preanesthetic level on 3rd postoperative day. The increase in band cell: segment cell ratio is prominent, whereas lymphocytes decreased significantly. Neutrophil chemotaxis and spontaneous migration were increased significantly from the end of operation to 1st postoperative day. NAP score, assumed to reflect the neutrophil phagocytic activity, lowered transiently during anesthesia, then increased 1.6 times more than preanesthetic level on 1st postoperative day. It was indicated that the increased cortisol release rather than adrenaline due to body response to surgical stress might induce neutrophilia, and that the elective spine surgery might not be deleterious to the neutrophil function.

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References

Cohen M, Pickar D, Dubois M . The role of the endogenous opioid system in the human stress response. Psychiatr Clin North Am. 1983; 6(3):457-71. View

Hallman H, Farnebo L, Hamberger B, Johnsson G . A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection. Life Sci. 1978; 23(10):1049-52. DOI: 10.1016/0024-3205(78)90665-3. View

van Dijk W, Verbrugh H, van Rijswijk R, Vos A, Verhoef J . Neutrophil function, serum opsonic activity, and delayed hypersensitivity in surgical patients. Surgery. 1982; 92(1):21-9. View

Moudgil G, Pandya A, Ludlow D . Influence of anaesthesia and surgery on neutrophil chemotaxis. Can Anaesth Soc J. 1981; 28(3):232-8. DOI: 10.1007/BF03005506. View

Pedersen B, Hayhoe F . Relation between phagocytic activity and alkaline phosphatase content of neutrophils in chronic myeloid leukaemia. Br J Haematol. 1971; 21(3):257-60. DOI: 10.1111/j.1365-2141.1971.tb03437.x. View

Roth J, KAEBERLE M, Hsu W . Effects of ACTH administration on bovine polymorphonuclear leukocyte function and lymphocyte blastogenesis. Am J Vet Res. 1982; 43(3):412-6. View

Simpkins C, Dickey C, Fink M . Human neutrophil migration is enhanced by beta-endorphin. Life Sci. 1984; 34(23):2251-5. DOI: 10.1016/0024-3205(84)90213-3. View

Frei P, Hermanovicz A, Pecoud A . Chemotaxis of human polymorphonuclears in vitro. V. Role of the nonsegmented neutrophils and of the experimental conditions in the impairment of chemotaxis observed during bacterial infections. J Lab Clin Med. 1978; 92(4):577-84. View

Solomkin J, Bauman M, Nelson R, Simmons R . Neutrophils dysfunction during the course of intra-abdominal infection. Ann Surg. 1981; 194(1):9-17. PMC: 1345188. DOI: 10.1097/00000658-198107000-00003. View

10.

Bardosi L, TEKERES M . Impaired metabolic activity of phagocytic cells after anaesthesia and surgery. Br J Anaesth. 1985; 57(5):520-3. DOI: 10.1093/bja/57.5.520. View

11.

Stevenson R, Gray A, Lucie N . Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function. Clin Exp Immunol. 1978; 33(3):478-85. PMC: 1537436. View

12.

SAMUELS A . Primary and secondary leucocyte changes following the intramuscular injection of epinephrine hydrochloride. J Clin Invest. 1951; 30(9):941-7. PMC: 436332. DOI: 10.1172/JCI102515. View

13.

Derbyshire D, Smith G . Sympathoadrenal responses to anaesthesia and surgery. Br J Anaesth. 1984; 56(7):725-39. DOI: 10.1093/bja/56.7.725. View

14.

VAN Oss C . Phagocytosis: an overview. Methods Enzymol. 1986; 132:3-15. DOI: 10.1016/s0076-6879(86)32003-2. View

15.

Brown 3rd F, Owens W, FELTS J, Spitznagel Jr E, Cryer P . Plasma epinephrine and norepinephrine levels during anesthesia: enflurane-N2O-O2 compared with fentanyl-N2O-O2. Anesth Analg. 1982; 61(4):366-70. View

16.

Guelfi J, Courdouhji M, Alvinerie M, Toutain P . In vivo and in vitro effects of three glucocorticoids on blood leukocyte chemotaxis in the dog. Vet Immunol Immunopathol. 1985; 10(2-3):245-52. DOI: 10.1016/0165-2427(85)90050-9. View

17.

Sullivan G, Patselas T, Redick J, Mandell G . Enhancement of chemotaxis and protection of mice from infection. Trans Assoc Am Physicians. 1984; 97:337-45. View

18.

Merkiel K, PROKOPOWICZ J, Krawczuk J . Neutrophil alkaline phosphatase activity in patients with neoplasma during surgical treatment. Neoplasma. 1981; 28(5):593-7. View

19.

Fletcher J . Effects of surgery on neutrophil granulocyte function. Infect Immun. 1981; 32(1):38-41. PMC: 350583. DOI: 10.1128/iai.32.1.38-41.1981. View

20.

Nelson R, Quie P, Simmons R . Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol. 1975; 115(6):1650-6. View