Taenia Solium Metacestode Glycoproteins As Diagnostic Antigens for Solitary Cysticercus Granuloma in Indian Patients

Overview

Journal Trans R Soc Trop Med Hyg

Publisher Oxford University Press

Specialties Public Health
Tropical Medicine

Date 2004 Jun 10

PMID 15186936

Citations 19

Authors

V Prabhakaran

V Rajshekhar

K D Murrell

A Oommen

Affiliations

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Abstract

Taenia solium metacestode glycoproteins specific for lentil lectin were evaluated as diagnostic antigens for solitary cysticercus granulomas in Indian patients, using both an ELISA and immunoblotting. In 250 patients suspected to have neurocysticercosis and subjected to a computerized tomography scan or magnetic resonance imaging, the proteins were diagnostic by the ELISA in 86 patients (80%) and by immunoblots in 67 (62%) of 107 patients with solitary cysticerus granuloma. Among 100 non-cysticercosis patients, the ELISA and immunoblot were negative in 94% and 97% respectively. No cross-reactions were observed with sera from patients with central nervous system tuberculosis. Proteins of </=18 kDa were the most diagnostic for solitary cysticercus granuloma.

Citing Articles

Accuracy of immunological tests on serum and urine for diagnosis of Taenia solium neurocysticercosis: A systematic review.

Van Acker L, Toribio L, Chachage M, Zeng H, Devleesschauwer B, Garcia H PLoS Negl Trop Dis. 2024; 18(11):e0012643.

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Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis.

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Correlation between Monocyte Gene Expression and Inflammation on Brain Imaging in Patients with Solitary Cerebral Cysticercus Granuloma.

Pamela B, Thamizhmaran S, Manoj J, Thanigachalam A, Carabin H, Prabhakaran V Am J Trop Med Hyg. 2023; 109(5):992-998.

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Monocyte Gene Expression Distinguishes Enhancing Brain Parenchymal Cysticercal Granulomas From Tuberculomas.

Pamela B, Vasudevan P, Thamizhmaran S, Moorthy R, Oommen A, Manoj J Open Forum Infect Dis. 2021; 8(9):ofab427.

PMID: 34557561 PMC: 8454506. DOI: 10.1093/ofid/ofab427.