[Carcinogenic and Co-carcinogenic Effects of Metals and Ethanol on Human Salivary Gland Tissue]

Overview

Journal HNO

Specialty Otorhinolaryngology

Date 2004 Jun 9

PMID 15184987

Citations 5

Authors

U A Harreus

P Baumeister

B C Wallner

A Berghaus

N H Kleinsasser

Affiliations

Soon will be listed here.

Abstract

Background: The etiology of malignomas of human salivary glands is examined.

Material And Methods: Macroscopic, healthy salivary gland tissue from 46 donors was harvested during surgery. Single cells were isolated by enzymatic digestion. These were then incubated for 60 min with Na(2)Cr(2)O(7), NiSO(4), CdSO(4), ZnCl(2) and ethanol. Additionally, incubation with Na(2)Cr(2)O(7) was combined with NiSO(4), CdSO(4), ZnCl(2) and ethanol. The influence of CdSO(4) was analyzed by altered combinations with Na(2)Cr(2)O(7) during incubation and by the DNA-repair period. Evaluation was performed using fluorescent staining and digital analysis.

Results: Of all of the substances tested, only Na(2)Cr(2)O(7) showed genotoxic effects. NiSO(4), ZnCl(2) and ethanol had neither genotoxic nor cofactorial impacts. CdSO(4), however, caused additional genotoxic effects in combination with Na(2)Cr(2)O(7), although it lacked direct genotoxic potential. A reduction of DNA-repair of Na(2)Cr(2)O(7)-induced oxidative damage by CdSO(4) could be demonstrated.

Conclusions: In this investigation, sodium dichromate was identified as genotoxic in association with human salivary gland tissue. These effects could be increased by CdSO(4), reinforcing DNA damage based on oxidative stress.

Citing Articles

Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review.

Ungureanu L, Gradinaru I, Ghiciuc C, Amalinei C, Geletu G, Petrovici C Medicina (Kaunas). 2023; 59(9).

PMID: 37763811 PMC: 10535338. DOI: 10.3390/medicina59091692.

[Genotoxic effects of insecticides in current use on mucosal epithelial cells from human tonsil tissue].

Tisch M, Faulde M, Maier H HNO. 2006; 55 Suppl 1:E15-22.

PMID: 17149631 DOI: 10.1007/s00106-006-1481-9.

[Effects of nicotine with special consideration given to tumorigenesis in the head and neck region].

Semmler M, Driemel O, Staudenmaier R, Froelich K, Kleinsasser N Mund Kiefer Gesichtschir. 2006; 10(6):395-401.

PMID: 17028845 DOI: 10.1007/s10006-006-0025-5.

[Does nicotine add to the carcinogenic strain of tobacco smoke?].

Kleinsasser N, Sassen A, Semmler M, Staudenmaier R, Harreus U, Richter E HNO. 2005; 54(5):369-72, 374-5.

PMID: 16170509 DOI: 10.1007/s00106-005-1327-x.

[Mini-organ cultures of human nasal mucosa. A model for eco-genotoxicological investigations].

Wallner B, Harreus U, Gamarra F, Sassen A, Kleinsasser N HNO. 2005; 53(12):1037-46.

PMID: 15912341 DOI: 10.1007/s00106-005-1243-0.

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