Nuclear Factor-kappaB: Its Role in Health and Disease

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2004 Jun 4

PMID 15175863

Citations 342

Authors

Ashok Kumar

Yasunari Takada

Aladin M Boriek

Bharat B Aggarwal

Affiliations

Soon will be listed here.

Abstract

Nuclear factor-kappaB (NF-kappaB) is a major transcription factor that plays an essential role in several aspects of human health including the development of innate and adaptive immunity. The dysregulation of NF-kappaB is associated with many disease states such as AIDS, atherosclerosis, asthma, arthritis, cancer, diabetes, inflammatory bowel disease, muscular dystrophy, stroke, and viral infections. Recent evidence also suggests that the dysfunction of NF-kappaB is a major mediator of some human genetic disorders. Appropriate regulation and control of NF-kappaB activity, which can be achieved by gene modification or pharmacological strategies, would provide a potential approach for the management of NF-kappaB related human diseases. This review summarizes the current knowledge of the physiological and pathophysiological functions of NF-kappaB and its possible role as a target of therapeutic intervention

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