HPV E6/E7: Insights into Their Regulatory Role and Mechanism in Signaling Pathways in HPV-associated Tumor

Overview

Journal Cancer Gene Ther

Specialties Genetics
Oncology
Pharmacology

Date 2023 Dec 15

PMID 38102462

Authors

Qiu Peng

Lujuan Wang

Liang Zuo

ShuiChao Gao

Xianjie Jiang

Yaqian Han

Jinguan Lin

Mingjing Peng

Nayiyuan Wu

Yanyan Tang

Hao Tian

Yujuan Zhou

Qianjin Liao

Affiliations

Soon will be listed here.

Abstract

Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV infection has been strongly associated with the development of many malignancies, such as cervical, anal and oral cancers. The viral oncoproteins E6 and E7 perform central roles on HPV-induced carcinogenic processes. During tumor development, it usually goes along with the activation of abnormal signaling pathways. E6 and E7 induces changes in cell cycle, proliferation, invasion, metastasis and other biological behaviors by affecting downstream tumor-related signaling pathways, thus promoting malignant transformation of cells and ultimately leading to tumorigenesis and progression. Here, we summarized that E6 and E7 proteins promote HPV-associated tumorigenesis and development by regulating the activation of various tumor-related signaling pathways, for example, the Wnt/β-catenin, PI3K/Akt, and NF-kB signaling pathway. We also discussed the importance of HPV-encoded E6 and E7 and their regulated tumor-related signaling pathways for the diagnosis and effective treatment of HPV-associated tumors.

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