Leptin Signaling

Overview

Journal Physiol Behav

Specialties Physiology
Psychiatry
Psychology
Social Sciences

Date 2004 May 26

PMID 15159169

Citations 122

Authors

Rexford S Ahima

Suzette Y Osei

Affiliations

Soon will be listed here.

Abstract

The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.

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