The Ever-increasing Complexities of the Exon Junction Complex

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2004 May 18

PMID 15145352

Citations 133

Authors

Thomas O Tange

Ajit Nott

Melissa J Moore

Affiliations

Soon will be listed here.

Abstract

Over the past decade many studies have revealed a complex web of interconnections between the numerous steps required for eukaryotic gene expression. One set of interconnections link nuclear pre-mRNA splicing and the subsequent metabolism of the spliced mRNAs. It is now apparent that the means of connection is a set of proteins, collectively called the exon junction complex, which are deposited as a consequence of splicing upstream of mRNA exon-exon junctions.

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