DEAH-RHA Helicase•Znf Cofactor Systems in Kinetoplastid RNA Editing and Evolutionarily Distant RNA Processes

Overview

Journal RNA Dis

Date 2016 Aug 20

PMID 27540585

Citations 4

Authors

Jorge Cruz-Reyes

Blaine H M Mooers

Zakaria Abu-Adas

Vikas Kumar

Shelly Gulati

Affiliations

Soon will be listed here.

Abstract

Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.

Citing Articles

Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed 'bifunctional' gRNA in mRNA A6.

Meehan J, McDermott S, Ivens A, Goodall Z, Chen Z, Yu Z Nucleic Acids Res. 2023; 51(13):6944-6965.

PMID: 37246647 PMC: 10359474. DOI: 10.1093/nar/gkad453.

Site-specific and substrate-specific control of accurate mRNA editing by a helicase complex in trypanosomes.

Kumar V, Ivens A, Goodall Z, Meehan J, Doharey P, Hillhouse A RNA. 2020; 26(12):1862-1881.

PMID: 32873716 PMC: 7668249. DOI: 10.1261/rna.076513.120.

Protein features for assembly of the RNA editing helicase 2 subcomplex (REH2C) in Trypanosome holo-editosomes.

Kumar V, Doharey P, Gulati S, Meehan J, Martinez M, Hughes K PLoS One. 2019; 14(4):e0211525.

PMID: 31034523 PMC: 6488192. DOI: 10.1371/journal.pone.0211525.

Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editing.

Cruz-Reyes J, Mooers B, Doharey P, Meehan J, Gulati S Wiley Interdiscip Rev RNA. 2018; 9(6):e1502.

PMID: 30101566 PMC: 6185801. DOI: 10.1002/wrna.1502.

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