Signaling Specificity by Ras Family GTPases is Determined by the Full Spectrum of Effectors They Regulate

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2004 May 15

PMID 15143186

Citations 141

Authors

Pablo Rodriguez-Viciana

Celine Sabatier

Frank McCormick

Affiliations

Soon will be listed here.

Abstract

Ras family GTPases (RFGs) regulate signaling pathways that control multiple biological processes. How signaling specificity among the closely related family members is achieved is poorly understood. We have taken a proteomics approach to signaling by RFGs, and we have analyzed interactions of a panel of RFGs with a comprehensive group of known and potential effectors. We have found remarkable differences in the ability of RFGs to regulate the various isoforms of known effector families. We have also identified several proteins as novel effectors of RFGs with differential binding specificities to the various RFGs. We propose that specificity among RFGs is achieved by the differential regulation of combinations of effector families as well as by the selective regulation of different isoforms within an effector family. An understanding of this new level of complexity in the signaling pathways regulated by RFGs is necessary to understand how they carry out their many cellular functions. It will also likely have critical implications in the treatment of human diseases such as cancer.

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