The ACE Gene Insertion/deletion Polymorphism and Elite Endurance Swimming

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2004 May 13

PMID 15138837

Citations 25

Authors

Georgios Tsianos

Julie Sanders

Sukhbir Dhamrait

Steve Humphries

Stan Grant

Hugh Montgomery

Affiliations

Soon will be listed here.

Abstract

Human physical performance is influenced by genetic factors. A variation in the human angiotensin I-converting enzyme (ACE) gene has been identified, in which the insertion (I) variant may be associated with elite endurance performance, and the deletion (D) variant seems overrepresented amongst elite sprinters and short-distance swimmer status. We might thus anticipate I-allele frequency to be elevated amongst swimmers competing over very much greater distances, and have examined this hypothesis. Thirty-five truly elite very-long-distance swimmers were classified as better at 1- to 10-km distances (n=19, SLD group) or those best at 25-km races (n=16, LLD group). Genotype frequencies (II versus ID versus DD) differed between the two groups: 6% versus 47% versus 47% for SLD, and 18.8% versus 75% versus 6.2% for LLD (P=0.01). I-allele frequency was 0.29 for the shorter distance swimmers, and 0.59 for the 25 km group. These data are consistent with an association of ACE I allele with longer distance swimming, and the ACE D allele with swimming shorter distances.

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References

Wesolowska E, Marcil M, Davignon J, Latour Y, Genest Jr J . Angiotensin converting enzyme insertion/deletion polymorphism in French Canadian subjects with premature coronary artery disease. Pathol Biol (Paris). 1998; 46(5):295-300. View

Dragovic T, Minshall R, Jackman H, Wang L, Erdos E . Kininase II-type enzymes. Their putative role in muscle energy metabolism. Diabetes. 1996; 45 Suppl 1:S34-7. DOI: 10.2337/diab.45.1.s34. View

Fatini C, Abbate R, Pepe G, Battaglini B, Gensini F, Ruggiano G . Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms. Eur Heart J. 2000; 21(8):633-8. DOI: 10.1053/euhj.1999.1738. View

Danser A, SCHALEKAMP M, Bax W, Van Den Brink A, Saxena P, Riegger G . Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation. 1995; 92(6):1387-8. DOI: 10.1161/01.cir.92.6.1387. View

Woods D, Hickman M, Jamshidi Y, Brull D, Vassiliou V, Jones A . Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet. 2001; 108(3):230-2. DOI: 10.1007/s004390100466. View

Peterlin B, Milanez T, Kobal J, Petrovic D, Grad A, Pogacnik T . DD genotype of the angiotensin-converting enzyme gene and stroke in Slovenian population. Pflugers Arch. 2000; 439(3 Suppl):R38-9. View

Folland J, Leach B, Little T, Hawker K, Myerson S, Montgomery H . Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp Physiol. 2000; 85(5):575-9. View

Benetos A, Gautier S, Ricard S, Topouchian J, Asmar R, Poirier O . Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation. 1996; 94(4):698-703. DOI: 10.1161/01.cir.94.4.698. View

Meira-Lima I, Pereira A, Mota G, Krieger J, Vallada H . Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans. Neurosci Lett. 2000; 293(2):103-6. DOI: 10.1016/s0304-3940(00)01512-3. View

10.

Woods D, Brull D, Montgomery H . Endurance and the ACE I/D polymorphism. Sci Prog. 2001; 83(Pt 4):317-36. View

11.

Schunkert H, Hense H, Holmer S, Stender M, Perz S, Keil U . Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med. 1994; 330(23):1634-8. DOI: 10.1056/NEJM199406093302302. View

12.

Badenhop R, Wang X, Wilcken D . Angiotensin-converting enzyme genotype in children and coronary events in their grandparents. Circulation. 1995; 91(6):1655-8. DOI: 10.1161/01.cir.91.6.1655. View

13.

Montgomery H, Marshall R, Hemingway H, Myerson S, Clarkson P, Dollery C . Human gene for physical performance. Nature. 1998; 393(6682):221-2. DOI: 10.1038/30374. View

14.

Myerson S, Hemingway H, Budget R, Martin J, Humphries S, Montgomery H . Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol (1985). 1999; 87(4):1313-6. DOI: 10.1152/jappl.1999.87.4.1313. View

15.

Hubacek J, Pitha J, Podrapska I, Sochman J, Adamkova V, Lanska V . Insertion/deletion polymorphism in the angiotensin-converting enzyme gene in myocardial infarction survivors. Med Sci Monit. 2001; 6(3):503-6. View

16.

Gayagay G, Yu B, Hambly B, Boston T, Hahn A, Celermajer D . Elite endurance athletes and the ACE I allele--the role of genes in athletic performance. Hum Genet. 1998; 103(1):48-50. DOI: 10.1007/s004390050781. View

17.

Pola R, Gaetani E, Santoliquido A, Gerardino L, Cattani P, Serricchio M . Abdominal aortic aneurysm in normotensive patients: association with angiotensin-converting enzyme gene polymorphism. Eur J Vasc Endovasc Surg. 2001; 21(5):445-9. DOI: 10.1053/ejvs.2001.1339. View