Abdominal Aortic Aneurysm in Normotensive Patients: Association with Angiotensin-converting Enzyme Gene Polymorphism

Overview

Journal Eur J Vasc Endovasc Surg

Publisher Elsevier

Specialties Cardiology & Vascular Diseases
Gastroenterology
General Surgery

Date 2001 May 16

PMID 11352521

Citations 8

Authors

R Pola

E Gaetani

A Santoliquido

L Gerardino

P Cattani

M Serricchio

P Tondi

R Flore

M Grande

P Carbonin

G Fadda

P Pola

Affiliations

Soon will be listed here.

Abstract

Objective And Design: to assess if deletion of the angiotensin-converting enzyme (ACE) gene is a risk factor for abdominal aortic aneurysms (AAAs) in normotensive patients.

Materials And Methods: ACE gene polymorphism was examined by polymerase chain reaction in 124 subjects with AAA and in 112 control subjects. AAA normotensive patients (group A, n=56) were compared to normotensive control subjects (group B, n =112) and to AAA hypertensive patients (group C, n =68). All subjects enrolled in this study were Caucasian and from central and southern Italy.

Results: the distribution of ACE genotypes was: normotensive patients with AAAs (group A): 3 II, 14 ID, 39 DD; normotensive control subjects (group B): 36 II, 48 ID, 28 DD; hypertensive patients with AAAs (group C): 14 II, 32 ID, 22 DD. The DD genotype was more common in group A than in control groups (A vs B p<0.001; A vs C p <0.001). The ID genotype was more common in group A as well (A vs B p <0.05; A vs C p <0.005).

Conclusions: our data suggest a role for ACE I/D gene polymorphism in the pathogenesis of AAA in normotensive patients.

Citing Articles

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Genes and abdominal aortic aneurysm.

Hinterseher I, Tromp G, Kuivaniemi H Ann Vasc Surg. 2010; 25(3):388-412.

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Angiotensin II and abdominal aortic aneurysms.

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Tsianos G, Sanders J, Dhamrait S, Humphries S, Grant S, Montgomery H Eur J Appl Physiol. 2004; 92(3):360-2.

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