Enantioselective Tandem O-nitroso Aldol/Michael Reaction

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2004 May 13

PMID 15137750

Citations 15

Authors

Yuhei Yamamoto

Norie Momiyama

Hisashi Yamamoto

Affiliations

Soon will be listed here.

Abstract

This communication presents studies that illustrated nitroso Diels-Alder adduct has been obtained in uniformly high enantioselectivity via a tandem nitroso aldol/Michael reaction using an amine catalyst. The regiochemical outcome of this construction is documented to be the opposite to that of the normal nitroso aldol reaction, which has been determined by X-ray analysis. The reaction of the enone with silver-BINAP catalyst has also been investigated in conjunction with the control of regiochemistry in a stepwise process.

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