Identification of Purine Inhibitors of Phosphodiesterase 7 (PDE7)

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2004 May 6

PMID 15125967

Citations 9

Authors

William J Pitts

Wayne Vaccaro

Tram Huynh

Katerina Leftheris

Jacques Y Roberge

Joseph Barbosa

Junqing Guo

Baerbel Brown

Andrew Watson

Karen Donaldson

Gary C Starling

Peter A Kiener

Michael A Poss

John H Dodd

Joel C Barrish

Affiliations

Soon will be listed here.

Abstract

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.

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