Synthesis and Biological Activity of Novel Substituted Pyridines and Purines Containing 2,4-thiazolidinedione

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2004 Apr 28

PMID 15110969

Citations 20

Authors

Bok Young Kim

Joong Bok Ahn

Hong Woo Lee

Sung Kwon Kang

Jung Hwa Lee

Jae Soo Shin

Soon Kil Ahn

Chung Il Hong

Seung Soo Yoon

Affiliations

Soon will be listed here.

Abstract

A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKA(y) mice in vivo. On the basis of their biological activities, 5-(4-[2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy]benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.

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