Discovery and SAR Development of 2-(phenylamino) Imidazolines As Prostacyclin Receptor Antagonists [corrected]

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2004 Mar 12

PMID 15013022

Citations 14

Authors

Robin D Clark

Alam Jahangir

Daniel Severance

Rick Salazar

Thomas Chang

David Chang

Mary Frances Jett

Steven Smith

Keith Bley

Affiliations

Soon will be listed here.

Abstract

On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity in the rat.

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