Synthesis of Angiogenesis-targeted Peptide and Hydrophobized Polyethylene Glycol Conjugate

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2004 Mar 12

PMID 15013013

Citations 3

Authors

Noriyuki Maeda

Yoshito Takeuchi

Miki Takada

Yukihiro Namba

Naoto Oku

Affiliations

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Abstract

For the purpose of cancer antineovascular therapy, a novel angiogenesis-targeted peptide, Ala-Pro-Arg-Pro-Gly, (APRPG) was attached to hydrophobized polyethylene glycol (distearoylphosphatidylethanolamine [DSPE]-PEG). DSPE-PEG and the 5-mer peptide were condensed with DCC-HOBt method. Liposome modified with this DSPE-PEG-APRPG conjugate highly accumulated in tumor of tumor-bearing mice.

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