Discovery and in Vitro Evaluation of Potent TrkA Kinase Inhibitors: Oxindole and Aza-oxindoles

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2004 Mar 12

PMID 15013000

Citations 43

Authors

Edgar R Wood

Lee Kuyper

Kimberly G Petrov

Robert N Hunter 3rd

Philip A Harris

Karen Lackey

Affiliations

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Abstract

The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.

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