Epidermal Growth Factor Receptor: Elements of Intracellular Communication

Overview

Journal J Membr Biol

Date 1992 Jun 1

PMID 1501243

Citations 23

Authors

S M Hernandez-Sotomayor

G Carpenter

Affiliations

Soon will be listed here.

Abstract

While EGF has an important function in cell growth regulation, the molecular mechanisms by which intracellular signal connect the EGF: receptor complex on the plasma membrane with the initiation of DNA synthesis and mitogenesis is not well understood. The discovery that rasGAP, PI-3 kinase and PLC-gamma 1 are substrates for the EGF receptor tyrosine kinase has provided a beginning in understanding the biochemistry underlying growth factor receptor transduction.

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Epidermal growth factor activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases.

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