Fhit is a Physiological Target of the Protein Kinase Src

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2004 Mar 10

PMID 15007172

Citations 21

Authors

Yuri Pekarsky

Preston N Garrison

Alexey Palamarchuk

Nicola Zanesi

Rami I Aqeilan

Kay Huebner

Larry D Barnes

Carlo M Croce

Affiliations

Soon will be listed here.

Abstract

The FHIT gene is a tumor suppressor that is frequently inactivated by genomic alterations at chromosomal region 3p14.2. In the last few years, a considerable amount of data describing inactivation of FHIT in a variety of human malignancies and demonstrating the tumor suppressor potential of Fhit have been reported. Despite the demonstration that FHIT functions as a tumor suppressor, the pathway through which Fhit induces apoptosis and inhibits growth of cancer cells is not known. Our data demonstrate that Fhit is a target of tyrosine phosphorylation by the Src protein kinase. We show that Src phosphorylates Y114 of Fhit in vitro and in vivo, providing insight into a biochemical pathway involved in Fhit signaling.

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The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit.

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Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor ApA Elucidates Its Inhibitory Action on Translation.

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Hazan I, Hofmann T, Aqeilan R PLoS Genet. 2016; 12(12):e1006436.

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Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ.

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