Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease

Overview

Journal Mol Interv

Specialty Molecular Biology

Date 2004 Mar 3

PMID 14993393

Citations 8

Authors

Karen J Ho

James K Liao

Affiliations

Soon will be listed here.

Abstract

Gender-based differences in the incidence of hypertensive and coronary artery disease, the development of atherosclerosis, and myocardial remodeling after infarction are attributable to the indirect effect of estrogen on risk factor profiles, such as cholesterol levels, glucose metabolism, and insulin levels. More recent evidence, however, suggests that activated estrogen receptor (ER) mediates signaling cascades that culminate in direct protective effects such as vasodilation, inhibition of response to vessel injury, limiting myocardial injury after infarction, and attenuating cardiac hypertrophy. Although the ER is usually thought of as a ligand-dependent transcription factor, it can also rapidly mobilize signals at the plasma membrane and in the cytoplasm. Thus, a greater understanding of ER function and regulation may lead to the development of highly specific therapeutics that mediate the prevention and treatment of cardiovascular diseases.

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References

Pappas T, Gametchu B, Watson C . Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding. FASEB J. 1995; 9(5):404-10. DOI: 10.1096/fasebj.9.5.7896011. View

McHugh N, Cook S, Schairer J, Bidgoli M, Merrill G . Ischemia- and reperfusion-induced ventricular arrhythmias in dogs: effects of estrogen. Am J Physiol. 1995; 268(6 Pt 2):H2569-73. DOI: 10.1152/ajpheart.1995.268.6.H2569. View

White R, Darkow D, LANG J . Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism. Circ Res. 1995; 77(5):936-42. DOI: 10.1161/01.res.77.5.936. View

Sullivan Jr T, Karas R, Aronovitz M, Faller G, Ziar J, Smith J . Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest. 1995; 96(5):2482-8. PMC: 185902. DOI: 10.1172/JCI118307. View

Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H . Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science. 1995; 270(5241):1491-4. DOI: 10.1126/science.270.5241.1491. View

Mangelsdorf D, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K . The nuclear receptor superfamily: the second decade. Cell. 1995; 83(6):835-9. PMC: 6159888. DOI: 10.1016/0092-8674(95)90199-x. View

Beato M, Herrlich P, Schutz G . Steroid hormone receptors: many actors in search of a plot. Cell. 1995; 83(6):851-7. DOI: 10.1016/0092-8674(95)90201-5. View

Chen S, Li H, Durand J, Oparil S, Chen Y . Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery. Circulation. 1996; 93(3):577-84. DOI: 10.1161/01.cir.93.3.577. View

Pimentel M, Parker M, McLachlan J, Korach K . Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol. Endocrinology. 1996; 137(5):1735-44. DOI: 10.1210/endo.137.5.8612509. View

10.

Migliaccio A, Di Domenico M, Castoria G, De Falco A, Bontempo P, Nola E . Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 1996; 15(6):1292-300. PMC: 450032. View

11.

Bunone G, Briand P, Miksicek R, Picard D . Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 1996; 15(9):2174-83. PMC: 450141. View

12.

Di Domenico M, Castoria G, Bilancio A, Migliaccio A, Auricchio F . Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. Cancer Res. 1996; 56(19):4516-21. View

13.

Bourassa P, Milos P, Gaynor B, Breslow J, Aiello R . Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 1996; 93(19):10022-7. PMC: 38329. DOI: 10.1073/pnas.93.19.10022. View

14.

Simoncini T, Hafezi-Moghadam A, Brazil D, Ley K, Chin W, Liao J . Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 2000; 407(6803):538-41. PMC: 2670482. DOI: 10.1038/35035131. View

15.

Migliaccio A, Castoria G, Di Domenico M, De Falco A, Bilancio A, Lombardi M . Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J. 2000; 19(20):5406-17. PMC: 314017. DOI: 10.1093/emboj/19.20.5406. View

16.

Watters J, Chun T, Kim Y, Bertics P, Gorski J . Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells. Mol Endocrinol. 2000; 14(11):1872-81. DOI: 10.1210/mend.14.11.0551. View

17.

Chambliss K, Yuhanna I, Mineo C, Liu P, German Z, Sherman T . Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res. 2000; 87(11):E44-52. DOI: 10.1161/01.res.87.11.e44. View

18.

Razandi M, Pedram A, Levin E . Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem. 2000; 275(49):38540-6. DOI: 10.1074/jbc.M007555200. View

19.

Feng W, Webb P, Nguyen P, Liu X, Li J, Karin M . Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. Mol Endocrinol. 2001; 15(1):32-45. DOI: 10.1210/mend.15.1.0590. View

20.

Pettersson K, Gustafsson J . Role of estrogen receptor beta in estrogen action. Annu Rev Physiol. 2001; 63:165-92. DOI: 10.1146/annurev.physiol.63.1.165. View