Host Genetic Polymorphisms in Human Immunodeficiency Virus-related Neurologic Disease

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2004 Feb 26

PMID 14982742

Citations 13

Authors

Ramon Diaz-Arrastia

Yunhua Gong

Cynthia J Kelly

Benjamin B Gelman

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to determine whether host genetic polymorphisms influence the risk of developing human immunodeficiency virus (HIV) encephalitis and vacuolar myelopathy. Allelic association studies were carried out with common polymorphisms in candidate genes that are postulated to play a role in the pathogenesis of HIV-related neurologic complications. The authors studied brains and spinal cords from 270 patients who died of acquired immunodeficiency syndrome (AIDS) from 1989 to 1996. All had complete gross and microscopic pathologic evaluations, and the presence of microglial nodules, multinucleated giant cells, myelin pallor, and vacuolar myelopathy was assessed by an experienced neuropathologist who was blinded to the genotype. DNA was extracted from frozen brain samples, and determination of the presence of the APOE4, TNF-2, IL-1B*2, ILIRN*2 polymorphisms was determined by polymerase chain reaction (PCR) and restricted fragment length polymorphism (RFLP) mapping. The authors did not detect a consistent association between inheritance of candidate polymorphic alleles and the pathologic findings of HIV encephalitis or vacuolar myelopathy. Allelic association studies with candidate genes are powerful techniques that have the potential to contribute to understanding the pathophysiology of HIV-related neurodegeneration. This preliminary study, although including a substantial number of patients, was not sufficiently powered to exclude a modest but clinically significant effects. Future studies will require much larger sample sizes and technical advances to allow screening at larger number of candidate loci.

Citing Articles

Transcriptomic and Genetic Profiling of HIV-Associated Neurocognitive Disorders.

Ojeda-Juarez D, Kaul M Front Mol Biosci. 2021; 8:721954.

PMID: 34778371 PMC: 8586712. DOI: 10.3389/fmolb.2021.721954.

Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.

Gomez D, Power C, Fujiwara E Curr Top Behav Neurosci. 2018; 50:41-76.

PMID: 30523615 DOI: 10.1007/7854_2018_69.

Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics.

Olivier I, Cacabelos R, Naidoo V Int J Mol Sci. 2018; 19(11).

PMID: 30441796 PMC: 6274730. DOI: 10.3390/ijms19113594.

Aging and Apolipoprotein E in HIV Infection.

Geffin R, McCarthy M J Neurovirol. 2018; 24(5):529-548.

PMID: 29987582 PMC: 6244718. DOI: 10.1007/s13365-018-0660-2.

Host genetic factors predisposing to HIV-associated neurocognitive disorder.

Kallianpur A, Levine A Curr HIV/AIDS Rep. 2014; 11(3):336-52.

PMID: 24996618 PMC: 4121535. DOI: 10.1007/s11904-014-0222-z.

References

Wilson A, Symons J, McDowell T, McDevitt H, Duff G . Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A. 1997; 94(7):3195-9. PMC: 20345. DOI: 10.1073/pnas.94.7.3195. View

Chapman J, Vinokurov S, Achiron A, Karussis D, Mitosek-Szewczyk K, Birnbaum M . APOE genotype is a major predictor of long-term progression of disability in MS. Neurology. 2001; 56(3):312-6. DOI: 10.1212/wnl.56.3.312. View

Cherner M, Masliah E, Ellis R, Marcotte T, Moore D, Grant I . Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis. Neurology. 2002; 59(10):1563-7. DOI: 10.1212/01.wnl.0000034175.11956.79. View

Tang M, Maestre G, Tsai W, Liu X, Feng L, Chung W . Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City. Am J Hum Genet. 1996; 58(3):574-84. PMC: 1914582. View

Lipton S . Neuronal injury associated with HIV-1: approaches to treatment. Annu Rev Pharmacol Toxicol. 1998; 38:159-77. DOI: 10.1146/annurev.pharmtox.38.1.159. View

Corder E, Robertson K, Lannfelt L, Bogdanovic N, Eggertsen G, Wilkins J . HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med. 1998; 4(10):1182-4. DOI: 10.1038/2677. View

Chapman J, Estupinan J, Asherov A, Goldfarb L . A simple and efficient method for apolipoprotein E genotype determination. Neurology. 1996; 46(5):1484-5. DOI: 10.1212/wnl.46.5.1484-a. View

Childs E, Lyles R, Selnes O, Chen B, Miller E, Cohen B . Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy. Neurology. 1999; 52(3):607-13. DOI: 10.1212/wnl.52.3.607. View

Mayeux R, Stern Y, Ottman R, Tatemichi T, Tang M, Maestre G . The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann Neurol. 1993; 34(5):752-4. DOI: 10.1002/ana.410340527. View

10.

Fazekas F, Strasser-Fuchs S, Kollegger H, Berger T, Kristoferitsch W, Schmidt H . Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis. Neurology. 2001; 57(5):853-7. DOI: 10.1212/wnl.57.5.853. View

11.

McGuire W, Hill A, Allsopp C, Greenwood B, Kwiatkowski D . Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature. 1994; 371(6497):508-10. DOI: 10.1038/371508a0. View

12.

Goldstein D . Islands of linkage disequilibrium. Nat Genet. 2001; 29(2):109-11. DOI: 10.1038/ng1001-109. View

13.

Plomin R, McClearn G, Smith D, Vignetti S, Chorney M, Chorney K . DNA markers associated with high versus low IQ: the IQ Quantitative Trait Loci (QTL) Project. Behav Genet. 1994; 24(2):107-18. DOI: 10.1007/BF01067815. View

14.

Dunlop O, Goplen A, Liestol K, Myrvang B, Rootwelt H, Christophersen B . HIV dementia and apolipoprotein E. Acta Neurol Scand. 1997; 95(5):315-8. DOI: 10.1111/j.1600-0404.1997.tb00217.x. View

15.

Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J . A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest. 1992; 22(6):396-402. DOI: 10.1111/j.1365-2362.1992.tb01480.x. View

16.

Lucotte G, Loirat F, Hazout S . Pattern of gradient of apolipoprotein E allele *4 frequencies in western Europe. Hum Biol. 1997; 69(2):253-62. View

17.

Griffin D . Cytokines in the brain during viral infection: clues to HIV-associated dementia. J Clin Invest. 1998; 100(12):2948-51. PMC: 508505. DOI: 10.1172/JCI119847. View

18.

Swindells S, Zheng J, Gendelman H . HIV-associated dementia: new insights into disease pathogenesis and therapeutic interventions. AIDS Patient Care STDS. 1999; 13(3):153-63. DOI: 10.1089/apc.1999.13.153. View

19.

dArminio Monforte A, Duca P, Vago L, Grassi M, Moroni M . Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy. Neurology. 2000; 54(9):1856-9. DOI: 10.1212/wnl.54.9.1856. View

20.

Nadel S, Newport M, Booy R, Levin M . Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease. J Infect Dis. 1996; 174(4):878-80. DOI: 10.1093/infdis/174.4.878. View