Islands of Linkage Disequilibrium

Overview

Journal Nat Genet

Specialty Genetics

Date 2001 Oct 5

PMID 11586289

Citations 76

Authors

D B Goldstein

Affiliations

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Abstract

A detailed knowledge of patterns of linkage disequilibrium in human populations is widely seen as a prerequisite for effective population-based disease gene mapping. New data suggest that linkage disequilibrium is highly structured into discrete blocks of sequence separated by hot spots of recombination.

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