The Formation of Collagen Fibers by the Action of Heparin on Soluble Collagen: an Electron Microscope Study

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1952 Aug 1

PMID 14955567

Citations 8

Authors

T G Morrione

Affiliations

Soon will be listed here.

Abstract

Collagen fibers have been formed in vitro by the action of heparm on solutions of collagen. Heparin was found to be effective in inducing collagen fiber formation when present in concentrations as low as 1-80,000. It is postulated that mast cells, by virtue of the heparin which they produce, may play a role in the formation of collagen.

Citing Articles

[The current status of research on mast cells].

Niebauer G Klin Wochenschr. 1960; 38:673-9.

PMID: 14427039 DOI: 10.1007/BF01486945.

Heparin in acute myocardial infarction: observations indicating the potential advantages of using it as the sole anticoagulant in therapy.

ENGELBERG H Calif Med. 1959; 91:327-31.

PMID: 13820324 PMC: 1577959.

[Humoral functions of leukocytes].

Remy D Klin Wochenschr. 1960; 38:900-2.

PMID: 13740799 DOI: 10.1007/BF01477995.

[On the presence and significance of tissue mast cells in human tonsils].

DRABE J Arch Ohren Nasen Kehlkopfheilkd. 1961; 177:174-86.

PMID: 13724202

[Results of research on connective tissue and its significance for disorders of the supporting and locomotion apparatus].

COTTA H, DETTMER N Arch Orthop Unfallchir. 1960; 52:217-46.

PMID: 13695863 DOI: 10.1007/BF00415932.

References

Highberger J, Gross J, SCHMITT F . The interaction of mucoprotein with soluble collagen; an electron microscope study. Proc Natl Acad Sci U S A. 1951; 37(5):286-91. PMC: 1063355. DOI: 10.1073/pnas.37.5.286. View

Meyer K, Rapport M . The mucopolysaccharides of the ground substance of connective tissue. Science. 1951; 113(2943):596-9. DOI: 10.1126/science.113.2943.596. View

VANAMEE P, PORTER K . Observations with the electron microscope on the solvation and reconstitution of collagen. J Exp Med. 1951; 94(3):255-66. PMC: 2136103. DOI: 10.1084/jem.94.3.255. View

EHRICH W . Nature of collagen diseases. Am Heart J. 1952; 43(1):121-56. DOI: 10.1016/0002-8703(52)90034-3. View

GERSH I, CATCHPOLE H . The organization of ground substance and basement membrane and its significance in tissue injury disease and growth. Am J Anat. 1949; 85(3):457-521, incl 7 pl. DOI: 10.1002/aja.1000850304. View