Influence of High-level Gentamicin Resistance and Beta-hemolysis on Susceptibility of Enterococci to the Bactericidal Activities of Ampicillin and Vancomycin

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1992 Nov 11

PMID 1489198

Citations 2

Authors

E Cercenado

G M Eliopoulos

C B Wennersten

R C Moellering Jr

Affiliations

Soon will be listed here.

Abstract

The bactericidal activities of ampicillin and vancomycin against 40 recent isolates of Enterococcus faecalis were examined by kill-kinetic studies at concentrations of 4 x the MIC and 20 micrograms/ml. Greater killing was seen with ampicillin (3.57 +/- 0.87 and 2.50 +/- 1.09 log10 CFU/ml, respectively; mean +/- standard deviation) than with vancomycin (1.23 +/- 0.65 and 1.05 +/- 0.57 log10 CFU/ml, respectively). Highly gentamicin-resistant strains showed a tendency toward reduced susceptibility to killing; beta-hemolytic strains were more susceptible than nonhemolytic strains when exposed to ampicillin at 20 micrograms/ml. Within each group, individual isolates demonstrated great variability in susceptibility to killing by the drugs.

Citing Articles

Susceptibility and Correlation with Hemolytic Phenotype.

Wright T, Boyle K, Duquin T, Crane J Infect Dis (Auckl). 2016; 9:39-44.

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Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides.

Gavalda J, Torres C, Tenorio C, Lopez P, Zaragoza M, Capdevila J Antimicrob Agents Chemother. 1999; 43(3):639-46.

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