PriA is Essential for Viability of the Escherichia Coli Topoisomerase IV ParE10(Ts) Mutant

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2004 Feb 6

PMID 14762016

Citations 11

Authors

Gianfranco Grompone

Vladimir Bidnenko

S Dusko Ehrlich

Benedicte Michel

Affiliations

Soon will be listed here.

Abstract

The parE10(Ts) mutation, which renders Escherichia coli thermosensitive for growth by inactivation of the essential E. coli topoisomerase topo IV, is lethal at all temperatures when PriA, the main replication restart protein, is absent. This lethality is suppressed by the activation of a PriA-independent replication restart pathway (dnaC809 mutation). This result suggests that topo IV acts prior to full-chromosome replication completion.

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