Health Status and Voice Outcome After Treatment for T1a Glottic Carcinoma

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2004 Jan 10

PMID 14714128

Citations 32

Authors

A Jeanne G E Peeters

Christine D L van Gogh

Kim M Goor

Irma M Verdonck-de Leeuw

Johannes A Langendijk

Hans F Mahieu

Affiliations

Soon will be listed here.

Abstract

Radiotherapy as well as endoscopic laser surgery as the most widely used treatment modalities for T1a glottic carcinoma cause minor morbidity and negligible mortality and result in more or less comparable, excellent cure and larynx preservation rates. Therefore, other outcome measures such as voice-related problems and health status are important factors in the choice of treatment for T1a glottic cancer. The present study focuses on voice-related problems in the daily life of patients treated by radiotherapy or endoscopic laser surgery for T1a glottic cancer. Self ratings on health status assessed by means of COOP/WONCA health status charts and voice problems evaluated with a validated voice-specific questionnaire (the Voice Handicap Index) and overall judgment on voice quality were obtained. A total of 102 patients (56 treated by endoscopic laser surgery and 46 treated by radiotherapy) with at least 1-year follow-up were included. Response scores were high: 52 (93%) patients after endoscopic laser surgery versus 40 (87%) patients after radiation therapy completed and returned the questionnaires. A high percentage of patients reported voice problems in daily life: 58% of the patients following radiotherapy and 40% of the patients following endoscopic treatment had abnormal VHI scores. The difference between both treatment modalities proved to be significant. No significant differences were found concerning health status or overall judgment of voice quality. Moderate correlations were found between total VHI score and voice quality judgment and the COOP/WONCA social activities chart. This study reveals that treatment for T1a glottic cancer often does result in voice problems in daily life, negatively influencing patients social activities. Patients selected for endoscopic laser surgery on average report fewer voice-related problems than those who underwent radiotherapy.

Citing Articles

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Multidimensional Voice Assessment After Management of Early Laryngeal Cancer: A Comparative Study.

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Evaluation of Voice After Definitive Radiotherapy in Patients of Early Stage Squamous Cell Carcinoma of Larynx (Glottis): A Prospective Observational Study.

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Evolution of voice after transoral laser cordectomy for precancerous lesions and early glottic cancer.

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References

Stoeckli S, Guidicelli M, Schneider A, Huber A, Schmid S . Quality of life after treatment for early laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2001; 258(2):96-9. DOI: 10.1007/s004050000307. View

Hirano M, Hirade Y, Kawasaki H . Vocal function following carbon dioxide laser surgery for glottic carcinoma. Ann Otol Rhinol Laryngol. 1985; 94(3):232-5. View

Katz M, Irish J, Devins G, Rodin G, Gullane P . Psychosocial adjustment in head and neck cancer: the impact of disfigurement, gender and social support. Head Neck. 2003; 25(2):103-12. DOI: 10.1002/hed.10174. View

Behrman A, Abramson A, Myssiorek D . A comparison of radiation-induced and presbylaryngeal dysphonia. Otolaryngol Head Neck Surg. 2001; 125(3):193-200. DOI: 10.1067/mhn.2001.117411. View

Cragle S, BRANDENBURG J . Laser cordectomy or radiotherapy: cure rates, communication, and cost. Otolaryngol Head Neck Surg. 1993; 108(6):648-54. DOI: 10.1177/019459989310800605. View

Myers E, Wagner R, Johnson J . Microlaryngoscopic surgery for T1 glottic lesions: a cost-effective option. Ann Otol Rhinol Laryngol. 1994; 103(1):28-30. DOI: 10.1177/000348949410300104. View

Fung K, Yoo J, Leeper H, Hawkins S, Heeneman H, Doyle P . Vocal function following radiation for non-laryngeal versus laryngeal tumors of the head and neck. Laryngoscope. 2002; 111(11 Pt 1):1920-4. DOI: 10.1097/00005537-200111000-00009. View

Koufman J . The endoscopic management of early squamous carcinoma of the vocal cord with the carbon dioxide surgical laser: clinical experience and a proposed subclassification. Otolaryngol Head Neck Surg. 1986; 95(5):531-7. DOI: 10.1177/019459988609500502. View

Wedman J, Heimdal J, Elstad I, Olofsson J . Voice results in patients with T1a glottic cancer treated by radiotherapy or endoscopic measures. Eur Arch Otorhinolaryngol. 2002; 259(10):547-50. DOI: 10.1007/s00405-002-0478-6. View

10.

Goor K, Mahieu H, Leemans C, Peeters A, Langendijk J, van Agthoven M . [CO2-laser decortication: an efficient alternative to radiotherapy in the treatment of T1a carcinomas of the glottis]. Ned Tijdschr Geneeskd. 2003; 147(24):1177-81. View

11.

Kelly M, Hahn S, Spaulding C, Kersh C, Constable W, Cantrell R . Definitive radiotherapy in the management of stage I and II carcinomas of the glottis. Ann Otol Rhinol Laryngol. 1989; 98(3):235-9. DOI: 10.1177/000348948909800314. View

12.

Delsupehe K, Zink I, Lejaegere M, Bastian R . Voice quality after narrow-margin laser cordectomy compared with laryngeal irradiation. Otolaryngol Head Neck Surg. 1999; 121(5):528-33. DOI: 10.1016/S0194-5998(99)70051-3. View

13.

Kaiser T, SESSIONS D, Harvey J . Natural history of treated T1N0 squamous carcinoma of the glottis. Ann Otol Rhinol Laryngol. 1989; 98(3):217-9. DOI: 10.1177/000348948909800311. View

14.

McGuirt W, Blalock D, Koufman J, Feehs R, Hilliard A, Greven K . Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch Otolaryngol Head Neck Surg. 1994; 120(9):951-5. DOI: 10.1001/archotol.1994.01880330035007. View

15.

STRONG M, Jako G . Laser surgery in the larynx. Early clinical experience with continuous CO 2 laser. Ann Otol Rhinol Laryngol. 1972; 81(6):791-8. DOI: 10.1177/000348947208100606. View

16.

Thomas J, Olsen K, Neel 3rd H, Desanto L, Suman V . Recurrences after endoscopic management of early (T1) glottic carcinoma. Laryngoscope. 1994; 104(9):1099-104. DOI: 10.1288/00005537-199409000-00009. View

17.

Rosier J, Gregoire V, Counoy H, Octave-Prignot M, Rombaut P, Scalliet P . Comparison of external radiotherapy, laser microsurgery and partial laryngectomy for the treatment of T1N0M0 glottic carcinomas: a retrospective evaluation. Radiother Oncol. 1998; 48(2):175-83. DOI: 10.1016/s0167-8140(98)00058-9. View

18.

Remacle M, Eckel H, Antonelli A, Brasnu D, Chevalier D, Friedrich G . Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society. Eur Arch Otorhinolaryngol. 2000; 257(4):227-31. DOI: 10.1007/s004050050228. View

19.

Kinnersley P, Peters T, Stott N . Measuring functional health status in primary care using the COOP-WONCA charts: acceptability, range of scores, construct validity, reliability and sensitivity to change. Br J Gen Pract. 1994; 44(389):545-9. PMC: 1239076. View

20.

BRANDENBURG J . Laser cordotomy versus radiotherapy: an objective cost analysis. Ann Otol Rhinol Laryngol. 2001; 110(4):312-8. DOI: 10.1177/000348940111000404. View