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Androgens Are Protective in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

Overview
Journal J Neuroimmunol
Specialty Neurology
Date 2003 Dec 31
PMID 14698857
Citations 69
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Abstract

A gender difference prevails in some murine strains of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Our results showed that castration of SJL males, a strain characterized by decreased susceptibility of males as compared to females, displayed increased disease severity. In contrast, castration had no effect on disease in C57BL/6 males, a strain in which no gender difference in EAE is observed. Regardless of whether endogenous androgens were protective in a given genetic background, supplemental androgen treatment was protective in gonadally intact males of both strains. These data provide a basis for the novel therapeutic use of supplemental testosterone for men with MS.

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