Alpha3beta1 Integrin-CD151, a Component of the Cadherin-catenin Complex, Regulates PTPmu Expression and Cell-cell Adhesion

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2003 Dec 24

PMID 14691142

Citations 70

Authors

Nibedita Chattopadhyay

Zemin Wang

Leonie K Ashman

Susann M Brady-Kalnay

Jordan A Kreidberg

Affiliations

Soon will be listed here.

Abstract

The beta1 family of integrins has been primarily studied as a set of receptors for the extracellular matrix. In this paper, we define a novel role for alpha3beta1 integrin in association with the tetraspanin CD151 as a component of a cell-cell adhesion complex in epithelial cells that directly stimulates cadherin-mediated adhesion. The integrin-tetraspanin complex affects epithelial cell-cell adhesion at the level of gene expression both by regulating expression of PTPmu and by organizing a multimolecular complex containing PKCbetaII, RACK1, PTPmu, beta-catenin, and E-cadherin. These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior.

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