Role of APC and DNA Mismatch Repair Genes in the Development of Colorectal Cancers

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2003 Dec 16

PMID 14672538

Citations 73

Authors

Satya Narayan

Deodutta Roy

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S. in 2003, accounting for about 10% of cancer deaths. Among the colon cancer patients, hereditary risk contributes approximately 20%. The main inherited colorectal cancers are the familial adenomatous polyposis (FAP) and the hereditary nonpolyposis colorectal cancers (HNPCC). The FAP and HNPCC are caused due to mutations in the adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes. The focus of this review is to summarize the functions of APC and MMR gene products in the development of colorectal cancers.

Citing Articles

The Potential of Metabolomics in Colorectal Cancer Prognosis.

Fu C, Liu X, Wang L, Hang D Metabolites. 2024; 14(12).

PMID: 39728489 PMC: 11677167. DOI: 10.3390/metabo14120708.

The Distribution and Predictive Factor of Extra-Pancreatic Malignancy Occurrence in Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm-A Ten-Year Follow-Up Case-Control Study in Taiwan.

Wang S, Wu C, Sung K, Tsou Y, Lin C, Lee M Cancers (Basel). 2024; 16(23).

PMID: 39682288 PMC: 11640256. DOI: 10.3390/cancers16234102.

The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers: Recent Trends and Future Perspectives.

Singh T, Sharma D, Sharma R, Tuli H, Haque S, Ramniwas S Cancers (Basel). 2024; 16(9).

PMID: 38730663 PMC: 11083332. DOI: 10.3390/cancers16091711.

Correlation between NGS panel-based mutation results and clinical information in colorectal cancer patients.

Cheng B, Xu L, Zhang Y, Yang H, Liu S, Ding S Heliyon. 2024; 10(7):e29299.

PMID: 38623252 PMC: 11016705. DOI: 10.1016/j.heliyon.2024.e29299.

Unraveling the role of disulfidptosis-related LncRNAs in colon cancer: a prognostic indicator for immunotherapy response, chemotherapy sensitivity, and insights into cell death mechanisms.

Chi H, Huang J, Yan Y, Jiang C, Zhang S, Chen H Front Mol Biosci. 2023; 10:1254232.

PMID: 37916187 PMC: 10617599. DOI: 10.3389/fmolb.2023.1254232.

References

Aberle H, Bauer A, Stappert J, Kispert A, Kemler R . beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997; 16(13):3797-804. PMC: 1170003. DOI: 10.1093/emboj/16.13.3797. View

Marsh D, Dahia P, Zheng Z, Liaw D, Parsons R, GORLIN R . Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet. 1997; 16(4):333-4. DOI: 10.1038/ng0897-333. View

Trzepacz C, Lowy A, Kordich J, Groden J . Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. J Biol Chem. 1997; 272(35):21681-4. DOI: 10.1074/jbc.272.35.21681. View

Orford K, Crockett C, Jensen J, Weissman A, Byers S . Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem. 1997; 272(40):24735-8. DOI: 10.1074/jbc.272.40.24735. View

Lynch H, de la Chapelle A . Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet. 1999; 36(11):801-18. PMC: 1734258. View

Sanz-Ortega J, Bryant B, Sanz-Esponera J, Asenjo J, Saez M, Torres A . LOH at the APC/MCC gene (5Q21) is frequent in early stages of non-small cell lung cancer. Pathol Res Pract. 1999; 195(10):677-80. DOI: 10.1016/S0344-0338(99)80058-2. View

OGorman D, Costello M, Weiss J, Firth S, Scott C . Decreased insulin-like growth factor-II/mannose 6-phosphate receptor expression enhances tumorigenicity in JEG-3 cells. Cancer Res. 1999; 59(22):5692-4. View

Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P . Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. Hum Mol Genet. 1999; 9(2):283-7. DOI: 10.1093/hmg/9.2.283. View

Toyota M, Ahuja N, Issa J . Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A. 2000; 97(2):710-5. PMC: 15395. DOI: 10.1073/pnas.97.2.710. View

10.

Ficari F, Cama A, Valanzano R, Curia M, Palmirotta R, Aceto G . APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis. Br J Cancer. 2000; 82(2):348-53. PMC: 2363293. DOI: 10.1054/bjoc.1999.0925. View

11.

ISHIDATE T, Matsumine A, Toyoshima K, Akiyama T . The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene. 2000; 19(3):365-72. DOI: 10.1038/sj.onc.1203309. View

12.

Gumbiner B . Regulation of cadherin adhesive activity. J Cell Biol. 2000; 148(3):399-404. PMC: 2174801. DOI: 10.1083/jcb.148.3.399. View

13.

Villani G, Le Gac N . Interactions of DNA helicases with damaged DNA: possible biological consequences. J Biol Chem. 2000; 275(43):33185-8. DOI: 10.1074/jbc.R000011200. View

14.

Zhang F, White R, Neufeld K . Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. Proc Natl Acad Sci U S A. 2000; 97(23):12577-82. PMC: 18806. DOI: 10.1073/pnas.230435597. View

15.

Townsley F, Bienz M . Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo. Curr Biol. 2000; 10(21):1339-48. DOI: 10.1016/s0960-9822(00)00770-3. View

16.

Collins R, Treisman J . Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Genes Dev. 2000; 14(24):3140-52. PMC: 317146. DOI: 10.1101/gad.854300. View

17.

Hannon G, Beach D . p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 1994; 371(6494):257-61. DOI: 10.1038/371257a0. View

18.

Hamilton S, Liu B, Parsons R, Papadopoulos N, Jen J, Powell S . The molecular basis of Turcot's syndrome. N Engl J Med. 1995; 332(13):839-47. DOI: 10.1056/NEJM199503303321302. View

19.

Liu B, Nicolaides N, Markowitz S, WILLSON J, Parsons R, Jen J . Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet. 1995; 9(1):48-55. DOI: 10.1038/ng0195-48. View

20.

Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J . Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science. 1995; 268(5215):1336-8. DOI: 10.1126/science.7761852. View