Extraintestinal Pathogenic Escherichia Coli As a Cause of Invasive Nonurinary Infections

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2003 Dec 10

PMID 14662987

Citations 45

Authors

James R Johnson

Abby Gajewski

Alan J Lesse

Thomas A Russo

Affiliations

Soon will be listed here.

Abstract

Multiple Escherichia coli isolates from four adults with extraintestinal infections underwent molecular phylotyping and virulence profiling. A patient with secondary peritonitis had two low-virulence E. coli strains from phylogenetic groups A and D. In contrast, three patients with invasive extraurinary infections (septic arthritis/pyomyositis, nontraumatic meningitis/hematogenous osteomyelitis, and pneumonia) each had a single high-virulence phylogenetic group B2 strain resembling typical isolates causing urinary infection and/or sepsis, i.e., extraintestinal pathogenic E. coli.

Citing Articles

The Effects of Diet, Dietary Supplements, Drugs and Exercise on Physical, Diagnostic Values of Urine Characteristics.

Skrajnowska D, Bobrowska-Korczak B Nutrients. 2024; 16(18).

PMID: 39339741 PMC: 11434675. DOI: 10.3390/nu16183141.

Genomic Dissection of an Enteroaggregative Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.

Del Carpio A, Freire C, Andrade F, Piazza R, Silva R, Carvalho E Int J Mol Sci. 2024; 25(17).

PMID: 39273188 PMC: 11394720. DOI: 10.3390/ijms25179238.

Genotypic Characterization of Uropathogenic from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.

Aurich S, Wolf S, Prenger-Berninghoff E, Thrukonda L, Semmler T, Ewers C Antibiotics (Basel). 2024; 13(1).

PMID: 38247597 PMC: 10812829. DOI: 10.3390/antibiotics13010038.

Safety, Reactogenicity, Immunogenicity, and Dose Selection of 10-Valent Extraintestinal Pathogenic Bioconjugate Vaccine (VAC52416) in Adults Aged 60-85 Years in a Randomized, Multicenter, Interventional, First-in-Human, Phase 1/2a Study.

Fierro C, Sarnecki M, Doua J, Spiessens B, Go O, Davies T Open Forum Infect Dis. 2023; 10(8):ofad417.

PMID: 37608916 PMC: 10442062. DOI: 10.1093/ofid/ofad417.

Bacterial drug-resistance patterns and genetic diversity of bacteria-associated bacteriuria in diabetic patients in Ghana.

Forson A, Menkah D, Quarchie M, Dhikrullahi S, Olu-Taiwo M, Codjoe F IJID Reg. 2022; 1:142-149.

PMID: 35757820 PMC: 9216422. DOI: 10.1016/j.ijregi.2021.10.007.

References

Johnson J, Russo T . Extraintestinal pathogenic Escherichia coli: "the other bad E coli". J Lab Clin Med. 2002; 139(3):155-62. DOI: 10.1067/mlc.2002.121550. View

Johnson J, OBryan T, Kuskowski M, Maslow J . Ongoing horizontal and vertical transmission of virulence genes and papA alleles among Escherichia coli blood isolates from patients with diverse-source bacteremia. Infect Immun. 2001; 69(9):5363-74. PMC: 98646. DOI: 10.1128/IAI.69.9.5363-5374.2001. View

Johnson J, Russo T . Uropathogenic Escherichia coli as agents of diverse non-urinary tract extraintestinal infections. J Infect Dis. 2002; 186(6):859-64. DOI: 10.1086/342490. View

Wang M, Tseng C, Chen C, Wu J, Huang J . The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection. Clin Infect Dis. 2002; 35(10):1161-6. DOI: 10.1086/343828. View

Somerville Jr J, Cassiano L, Darveau R . Escherichia coli msbB gene as a virulence factor and a therapeutic target. Infect Immun. 1999; 67(12):6583-90. PMC: 97070. DOI: 10.1128/IAI.67.12.6583-6590.1999. View

Russo T, Johnson J . Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC. J Infect Dis. 2000; 181(5):1753-4. DOI: 10.1086/315418. View

Molle I, Thulstrup A, Svendsen N, Schonheyder H, Sorensen H . Risk and case fatality rate of meningitis in patients with liver cirrhosis. Scand J Infect Dis. 2000; 32(4):407-10. DOI: 10.1080/003655400750044999. View

Guyer D, Henderson I, Nataro J, Mobley H . Identification of sat, an autotransporter toxin produced by uropathogenic Escherichia coli. Mol Microbiol. 2000; 38(1):53-66. DOI: 10.1046/j.1365-2958.2000.02110.x. View

Le Bouguenec C, Lalioui L, du Merle L, Jouve M, Courcoux P, Bouzari S . Characterization of AfaE adhesins produced by extraintestinal and intestinal human Escherichia coli isolates: PCR assays for detection of Afa adhesins that do or do not recognize Dr blood group antigens. J Clin Microbiol. 2001; 39(5):1738-45. PMC: 88018. DOI: 10.1128/JCM.39.5.1738-1745.2001. View

10.

Russo T, Johnson J . Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect. 2003; 5(5):449-56. DOI: 10.1016/s1286-4579(03)00049-2. View

11.

Johnson J, Kuskowski M, Owens K, Gajewski A, Winokur P . Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans. J Infect Dis. 2003; 188(5):759-68. DOI: 10.1086/377455. View

12.

Kaijser B, Larsson P, Olling S, Schneerson R . Protection against acute, ascending pyelonephritis caused by Escherichia coli in rats, using isolated capsular antigen conjugated to bovine serum albumin. Infect Immun. 1983; 39(1):142-6. PMC: 347916. DOI: 10.1128/iai.39.1.142-146.1983. View

13.

COX F, Taylor L . Prevention of Escherichia coli K1 bacteremia in newborn mice by using topical vaginal carbohydrates. J Infect Dis. 1990; 162(4):978-81. DOI: 10.1093/infdis/162.4.978. View

14.

Soriano G, Coll P, Guarner C, Such J, Sanchez F, Prats G . Escherichia coli capsular polysaccharide and spontaneous bacterial peritonitis in cirrhosis. Hepatology. 1995; 21(3):668-73. View

15.

Yamamoto T, Echeverria P . Detection of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene sequences in enterotoxigenic E. coli strains pathogenic for humans. Infect Immun. 1996; 64(4):1441-5. PMC: 173940. DOI: 10.1128/iai.64.4.1441-1445.1996. View

16.

Bertin Y, Martin C, Oswald E, Girardeau J . Rapid and specific detection of F17-related pilin and adhesin genes in diarrheic and septicemic Escherichia coli strains by multiplex PCR. J Clin Microbiol. 1996; 34(12):2921-8. PMC: 229434. DOI: 10.1128/jcm.34.12.2921-2928.1996. View

17.

Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner J, Burlein J . Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science. 1997; 276(5312):607-11. DOI: 10.1126/science.276.5312.607. View

18.

Pauwels A, Pines E, Abboura M, Chiche I, LEVY V . Bacterial meningitis in cirrhosis: review of 16 cases. J Hepatol. 1998; 27(5):830-4. DOI: 10.1016/s0168-8278(97)80320-0. View

19.

Bertin Y, Martin C, Girardeau J, Pohl P, Contrepois M . Association of genes encoding P fimbriae, CS31A antigen and EAST 1 toxin among CNF1-producing Escherichia coli strains from cattle with septicemia and diarrhea. FEMS Microbiol Lett. 1998; 162(2):235-9. DOI: 10.1111/j.1574-6968.1998.tb13004.x. View

20.

Bauer R, Zhang L, Foxman B, Siitonen A, Jantunen M, Saxen H . Molecular epidemiology of 3 putative virulence genes for Escherichia coli urinary tract infection-usp, iha, and iroN(E. coli). J Infect Dis. 2002; 185(10):1521-4. DOI: 10.1086/340206. View