» Articles » PMID: 14644182

Beyond A, C, G and T: Augmenting Nature's Alphabet

Overview
Publisher Elsevier
Specialty Biochemistry
Date 2003 Dec 4
PMID 14644182
Citations 70
Authors
Affiliations
Soon will be listed here.
Abstract

Efforts to expand the genetic alphabet are predicated upon a stable and replicable third base pair. Recent progress has resulted in the development of several candidates that are both stable in duplex DNA and replicated by DNA polymerases with various degrees of efficiency and fidelity. The candidate base pairs draw upon unnatural hydrogen-bonding topologies as well as upon shape complementarity and hydrophobic forces. This review provides a critical comparison of the third base pair candidates and discusses the further work required to expand the genetic alphabet.

Citing Articles

Force-induced melting and S-DNA pathways for DNA overstretching exhibit distinct kinetics.

Sundar Rajan V, Levin S, McCauley M, Williams M, Rouzina I, Wilhelmsson L Nucleic Acids Res. 2024; 53(1.

PMID: 39657777 PMC: 11724298. DOI: 10.1093/nar/gkae1183.


Investigation of the Nonradiative Photoprocesses of Unnatural DNA Base: 7-(2-Thienyl)-imidazo[4,5-]pyridine (Ds)─A Computational Study.

Ghosh P J Phys Chem A. 2024; 128(38):8065-8071.

PMID: 39279655 PMC: 11440586. DOI: 10.1021/acs.jpca.4c04070.


A Prebiotic Genetic Nucleotide as an Early Darwinian Ancestor for Pre-RNA Evolution.

Sawant A, Tripathi S, Galande S, Rajamani S ACS Omega. 2024; 9(16):18072-18082.

PMID: 38680342 PMC: 11044211. DOI: 10.1021/acsomega.3c09949.


Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet.

Viner C, Ishak C, Johnson J, Walker N, Shi H, Sjoberg-Herrera M Genome Biol. 2024; 25(1):11.

PMID: 38191487 PMC: 10773111. DOI: 10.1186/s13059-023-03070-0.


Cobalt-assisted route to rare carbocyclic -ribonucleosides.

Ojeda-Porras A, Roy V, Bourzikat O, Favetta P, Agrofoglio L RSC Adv. 2023; 13(44):30777-30786.

PMID: 37869399 PMC: 10587889. DOI: 10.1039/d3ra04937j.