Venous Leg Ulcers: a Prognostic Index to Predict Time to Healing

Overview

Journal BMJ

Specialty General Medicine

Date 1992 Nov 7

PMID 1463945

Citations 29

Authors

A I Skene

J M Smith

C J Dore

A Charlett

J D Lewis

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the prognostic factors in uncomplicated venous leg ulcer healing.

Design: Randomised parallel group controlled trial with subjects stratified by initial ulcer diameter and four months' maximum duration of follow up.

Setting: Assessment at Northwick Park Hospital vascular unit with community based treatment.

Patients: 200 patients with clinical and objective evidence of uncomplicated venous leg ulceration and an initial ulcer diameter > 2 cm.

Main Outcome Measure: Time to complete healing of the ulcer.

Results: In the presence of graduated compression healing occurred more rapidly in patients with a smaller initial ulcer area (relative risk of healing 1.92 associated with halving of ulcer area (95% confidence interval 1.58 to 2.33)), shorter duration of ulceration (relative risk 1.35 associated with halving duration (1.17 to 1.56)), younger age (relative risk 1.34 associated with 10 year decrease (1.12 to 1.59)), and no deep vein involvement (relative risk 1.8 (1.19 to 2.78)).

Conclusion: These prognostic factors used in a simple scoring system predict time to healing.

Citing Articles

Prognostic models for clinical outcomes in patients with venous leg ulcers: A systematic review.

Velickovic V, Macmillan T, Kottner J, Crompton A, Munro I, Paine A J Vasc Surg Venous Lymphat Disord. 2023; 12(1):101673.

PMID: 37689364 PMC: 11523447. DOI: 10.1016/j.jvsv.2023.06.017.

Clinical and histopathological responses to bee venom phonophoresis in treating venous and diabetic ulcers: a single-blind randomized controlled trial.

Othman E, Hamada H, Mohamed G, Abdallah G, Ahmed Z, Al-Shenqiti A Front Med (Lausanne). 2023; 10:1085544.

PMID: 37153087 PMC: 10157245. DOI: 10.3389/fmed.2023.1085544.

The effectiveness of two different sub-bandage pressure values on healing and quality of life outcomes for patients with venous leg ulcers.

Karanikolic V, Ignjatovic A, Marinkovic M, Djordjevic L Postepy Dermatol Alergol. 2023; 40(1):47-53.

PMID: 36909910 PMC: 9993218. DOI: 10.5114/ada.2022.124709.

Venous leg ulcers treated with fish collagen gel in a 12-week randomized single-centre study.

Cwajda-Bialasik J, Moscicka P, Szewczyk M, Hojan-Jezierska D, Kawalkiewicz W, Majewska A Postepy Dermatol Alergol. 2022; 39(4):714-722.

PMID: 36090717 PMC: 9454363. DOI: 10.5114/ada.2021.108424.

Evaluation of LL-37 in healing of hard-to-heal venous leg ulcers: A multicentric prospective randomized placebo-controlled clinical trial.

Mahlapuu M, Sidorowicz A, Mikosinski J, Krzyzanowski M, Orleanski J, Twardowska-Saucha K Wound Repair Regen. 2021; 29(6):938-950.

PMID: 34687253 PMC: 9298190. DOI: 10.1111/wrr.12977.

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