Comprehensive Review of the Clinical Application of Autologous Mesenchymal Stem Cells in the Treatment of Chronic Wounds and Diabetic Bone Healing

Overview

Journal Int Wound J

Specialties Emergency Medicine
Orthopedics

Date 2012 Mar 1

PMID 22372562

Citations 6

Authors

Gerit D Mulder

Daniel K Lee

Nathan S Jeppesen

Affiliations

Soon will be listed here.

Abstract

Chronic ulcerations are a physical and financial burden to the health and economic establishment in the United States and Worldwide. Improvements in biotechnology and knowledge in stem cell applications have progressed and basic science results are making their way slowly into the clinical arena. Chronic wounds and diabetic bone healing are the key components in the limb salvage of the common diabetic foot. We have examined the current available literature and present the latest on stem cells applications as a novel clinical technique in the treatment of chronic wound and diabetic bone healing and their impact in the treatment paradigm of patients.

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References

Yamaguchi Y, Kubo T, Murakami T, Takahashi M, Hakamata Y, Kobayashi E . Bone marrow cells differentiate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing. Br J Dermatol. 2005; 152(4):616-22. DOI: 10.1111/j.1365-2133.2005.06402.x. View

Bruder S, Jaiswal N, Ricalton N, Mosca J, Kraus K, Kadiyala S . Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res. 1999; (355 Suppl):S247-56. DOI: 10.1097/00003086-199810001-00025. View

Dash N, Dash S, Routray P, Mohapatra S, Mohapatra P . Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Res. 2009; 12(5):359-66. DOI: 10.1089/rej.2009.0872. View

Livingston T, Gordon S, Archambault M, Kadiyala S, McIntosh K, Smith A . Mesenchymal stem cells combined with biphasic calcium phosphate ceramics promote bone regeneration. J Mater Sci Mater Med. 2004; 14(3):211-8. DOI: 10.1023/a:1022824505404. View

Vojtassak J, Danisovic L, Kubes M, Bakos D, Jarabek L, Ulicna M . Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot. Neuro Endocrinol Lett. 2006; 27 Suppl 2:134-7. View

Lataillade J, Doucet C, Bey E, Carsin H, Huet C, Clairand I . New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med. 2007; 2(5):785-94. DOI: 10.2217/17460751.2.5.785. View

Arinzeh T, Peter S, Archambault M, van den Bos C, Gordon S, Kraus K . Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect. J Bone Joint Surg Am. 2003; 85(10):1927-35. DOI: 10.2106/00004623-200310000-00010. View

Bianco P, Riminucci M, Gronthos S, Robey P . Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells. 2001; 19(3):180-92. DOI: 10.1634/stemcells.19-3-180. View

Badiavas E, Falanga V . Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol. 2003; 139(4):510-6. DOI: 10.1001/archderm.139.4.510. View

10.

Yoshikawa T, Mitsuno H, Nonaka I, Sen Y, Kawanishi K, Inada Y . Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg. 2008; 121(3):860-877. DOI: 10.1097/01.prs.0000299922.96006.24. View

11.

Smith A, Willis E, Chan V, Muffley L, Isik F, Gibran N . Mesenchymal stem cells induce dermal fibroblast responses to injury. Exp Cell Res. 2009; 316(1):48-54. PMC: 2787776. DOI: 10.1016/j.yexcr.2009.08.001. View

12.

Kirana S, Stratmann B, Lammers D, Negrean M, Stirban A, Minartz P . Wound therapy with autologous bone marrow stem cells in diabetic patients with ischaemia-induced tissue ulcers affecting the lower limbs. Int J Clin Pract. 2007; 61(4):690-2. DOI: 10.1111/j.1742-1241.2007.01303.x. View

13.

Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N . Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng. 2007; 13(6):1299-312. DOI: 10.1089/ten.2006.0278. View

14.

Jaiswal N, Haynesworth S, Caplan A, Bruder S . Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997; 64(2):295-312. View

15.

Rogers L, Bevilacqua N, Armstrong D . The use of marrow-derived stem cells to accelerate healing in chronic wounds. Int Wound J. 2008; 5(1):20-5. PMC: 7951309. DOI: 10.1111/j.1742-481X.2007.00349.x. View

16.

Yu M, Zhou W, Song Y, Yu F, Li D, Na S . Development of mesenchymal stem cell-implant complexes by cultured cells sheet enhances osseointegration in type 2 diabetic rat model. Bone. 2011; 49(3):387-94. DOI: 10.1016/j.bone.2011.05.025. View

17.

Borue X, Lee S, Grove J, Herzog E, Harris R, Diflo T . Bone marrow-derived cells contribute to epithelial engraftment during wound healing. Am J Pathol. 2004; 165(5):1767-72. PMC: 1618655. DOI: 10.1016/S0002-9440(10)63431-1. View

18.

Rush S, Hamilton G, Ackerson L . Mesenchymal stem cell allograft in revision foot and ankle surgery: a clinical and radiographic analysis. J Foot Ankle Surg. 2009; 48(2):163-9. DOI: 10.1053/j.jfas.2008.12.008. View

19.

Phillips T . Chronic cutaneous ulcers: etiology and epidemiology. J Invest Dermatol. 1994; 102(6):38S-41S. DOI: 10.1111/1523-1747.ep12388556. View

20.

Mulder G, Lee D, Faghihnia N . Autologous bone marrow-derived stem cells for chronic wounds of the lower extremity: a retrospective study. Wounds. 2015; 22(9):219-25. View