Mannosyl Glycodendritic Structure Inhibits DC-SIGN-mediated Ebola Virus Infection in Cis and in Trans

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2003 Nov 26

PMID 14638512

Citations 31

Authors

Fatima Lasala

Eva Arce

Joaquin R Otero

Javier Rojo

Rafael Delgado

Affiliations

Soon will be listed here.

Abstract

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

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