Mouse Embryonic Chimeras: Tools for Studying Mammalian Development

Overview

Journal Development

Specialty Biology

Date 2003 Nov 19

PMID 14623817

Citations 83

Authors

Patrick P L Tam

Janet Rossant

Affiliations

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Abstract

Embryonic chimeras of the mouse are well-established tools for studying cell lineage and cell potential. They are also a key part of the analysis of complex phenotypes of mutant mice. By combining embryonic stem cell technology, molecularly tagged mutations and sensitive cell lineage markers, chimeras can provide invaluable insights into the tissue-specific requirement and the mode of action of many mouse genes.

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