» Articles » PMID: 14623315

Identification of Liver-intestine Cadherin in Hepatocellular Carcinoma--a Potential Disease Marker

Overview
Publisher Elsevier
Specialty Biochemistry
Date 2003 Nov 19
PMID 14623315
Citations 22
Authors
Affiliations
Soon will be listed here.
Abstract

Liver-intestine cadherin (LI-cad) is a non-classical cadherin, which is expressed during intestinal development, but absent in normal liver tissue. Our earlier investigation has detected overexpression of LI-cad in gastric adenocarcinoma and indicated its association with lymph node metastasis. Herein, we found in RT-PCR and TaqMan Q-PCR that LI-cad was identified in HCC cell lines, HuH-7, Hep-3B, and PLC/PRF/5, but not in MIHA and HepG2 non-tumorigenic cells. Immunofluorescence cytochemistry assay revealed that the LI-cad was predominantly expressed in cytoplasm of HCC cells, contrary to that of E-cad immunostain at the plasma membrane region. By testing against 18 pairs of HCC and adjacent non-tumor tissues, 13 cases (72.2%) showed over expression of LI-cad in HCC tissues, 2 cases (11.1%) were similar, and 3 cases did not yield detectable signal. None of the 6 normal liver specimens tested was positive with LI-cad. Taken together, LI-cad could be a potential disease marker for HCC.

Citing Articles

Tissue Cadherin 17 (CDH17): An Important Prognostic Determinant of Colorectal Cancer Using Digital Image Analysis.

Ng L, Yu W, Aung N, Leung P, Luk J, Wong D Cancer Rep (Hoboken). 2024; 7(12):e70069.

PMID: 39617741 PMC: 11608892. DOI: 10.1002/cnr2.70069.


Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism.

Gray M, Sotomayor M Acta Crystallogr F Struct Biol Commun. 2021; 77(Pt 3):85-94.

PMID: 33682793 PMC: 7938635. DOI: 10.1107/S2053230X21002247.


Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis.

Casal J, Bartolome R Int J Mol Sci. 2019; 20(13).

PMID: 31324051 PMC: 6651558. DOI: 10.3390/ijms20133373.


Generation of functional hepatocyte 3D discoids in an acoustofluidic bioreactor.

Khedr M, Messaoudi W, Jonnalagadda U, Abdelmotelb A, Glynne-Jones P, Hill M Biomicrofluidics. 2019; 13(1):014112.

PMID: 30867882 PMC: 6404912. DOI: 10.1063/1.5082603.


Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma.

Shek F, Luo R, Lam B, Sung W, Lam T, Luk J Cell Oncol (Dordr). 2017; 40(5):443-456.

PMID: 28631187 DOI: 10.1007/s13402-017-0332-x.