Peptide-induced Conformational Changes in Class I Heavy Chains Alter Major Histocompatibility Complex Recognition

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1992 Dec 1

PMID 1460430

Citations 26

Authors

J A Bluestone

S Jameson

S Miller

R Dick 2nd

Affiliations

Soon will be listed here.

Abstract

Small peptides, derived from endogenous proteins bind within the antigen binding groove created by the beta-pleated sheets and alpha helices of the alpha 1 and alpha 2 domains of the class I molecule of the major histocompatibility complex (MHC). However, the precise role of peptide in class I MHC conformation remains unclear. Here, we have shown that, in at least some instances, changes induced in the MHC molecule by the binding of distinct peptides can be identified as specific alterations in serological epitopes expressed on the class I protein. The nature of specific peptides expressed by class I-bearing cells may, therefore, have a dramatic influence on T cell development, self-tolerance, and alloreactivity.

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