Possible Role of Intestinal Alkaline Phosphatase Activity in Thiamine Transport

Overview

Journal Experientia

Specialty Science

Date 1978 Jan 15

PMID 145948

Citations 2

Authors

T Matsuda

A Baba

H Iwata

Affiliations

Soon will be listed here.

Abstract

Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++-and (Na+ + K+)-ATPase activities did not change after the administration of ethanol. These findings show that the al-Pase activity, unlike the Ca++-ATPase activity, is not related to Ca++-absorption. A possible role of al-Pase activity in the active transport of thiamine in the intestine was discussed.

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