Potassium Channel Regulation

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2003 Nov 1

PMID 14593442

Citations 30

Authors

Jeff D Campbell

Mark S P Sansom

Frances M Ashcroft

Affiliations

Soon will be listed here.

Abstract

The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis of these functional differences, we have constructed a molecular model of the NBD dimer of human SUR1. We discuss the experimental data in the context of this model, and show how the model can be used to design experiments aimed at elucidating the relationship between the structure and function of the KATP channel.

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