SAR of 3,4-dihydropyrido[3,2-d]pyrimidone P38 Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2003 Nov 1

PMID 14592489

Citations 11

Authors

Luping Liu

John E Stelmach

Swaminathan R Natarajan

Meng-Hsin Chen

Suresh B Singh

Cheryl D Schwartz

Catherine E Fitzgerald

Stephen J OKeefe

Dennis M Zaller

Dennis M Schmatz

James B Doherty

Affiliations

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Abstract

Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets in p38 active site is also discussed.

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