A Proposed Function for Spermine and Spermidine: Protection of Replicating DNA Against Damage by Singlet Oxygen

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1992 Dec 1

PMID 1454830

Citations 39

Authors

A U Khan

Y H Mei

T Wilson

Affiliations

Soon will be listed here.

Abstract

Like all aliphatic amines, the polyamines spermine and spermidine are physical quenchers of singlet molecular oxygen (1O2*). The rate constants of these processes were determined in vitro with photochemically generated 1O2* and the hydrocarbon rubrene as substrate, in pyridine. At millimolar concentration, spermine and spermidine should quench 1O2* in vivo and prevent it from damaging DNA. It is proposed that a biological function of polyamines is the protection of replicating DNA against oxidative damage.

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