The Intramolecular Carboxyarylation Approach to Podophyllotoxin

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2003 Oct 2

PMID 14518993

Citations 8

Authors

Aaron J Reynolds

Andrew J Scott

Craig I Turner

Michael S Sherburn

Affiliations

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Abstract

Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial production. Two are semisynthetic derivatives of podophyllotoxin. This paper describes concise, highly convergent, and conceptually novel approaches to (-)-podophyllotoxin and its enantiomer. These highly convergent syntheses feature a late-stage domino radical reaction to install the lactone ring and the pendant trimethoxyphenyl group.

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