Development of GPIIb/IIIa Antagonists As Antithrombotic Drugs

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 1992 Nov 11

PMID 1440877

Citations 7

Authors

A J Nichols

R R Ruffolo Jr

W F Huffman

G Poste

J Samanen

Affiliations

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Abstract

Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the leading cause of morbidity and mortality in the Western world. This review by Andy Nichols and colleagues focuses on a central process in thrombosis, namely platelet aggregation, and how it can be inhibited by antagonists of the adhesion molecule GPIIb/IIIa. Successful and future therapeutic applications of GPIIb/IIIa antagonists, and their pharmacology, are considered in detail.

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