Processing and Localization of Dengue Virus Type 2 Polyprotein Precursor NS3-NS4A-NS4B-NS5

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1992 Dec 1

PMID 1433530

Citations 46

Authors

L Zhang

P M Mohan

R Padmanabhan

Affiliations

Soon will be listed here.

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

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