THE NEUROLOGICAL AND DEVELOPMENTAL EFFECTS OF NEONATAL HYPOGLYCEMIA: A FOLLOW-UP OF 22 CASES

Overview

Journal Can Med Assoc J

Specialty General Medicine

Date 1965 Apr 17

PMID 14282940

Citations 9

Authors

J C Haworth

K N MCRAE

Affiliations

Soon will be listed here.

Abstract

Twenty-two infants in whom hypoglycemia (blood sugar less than 20 mg./100 ml.) was noted during the first few days of life were followed up when eight to 30 months of age. In eight such symptoms as muscular tremors, cyanosis, apneic spells and convulsions were associated with the hypoglycemia; five of these had abnormal central nervous system signs and retarded development. One other had possible impairment of development and another had a recurrence of hypoglycemia after having been well for four years. Fourteen of the 22 infants had no symptoms associated with the hypoglycemia, and on follow-up only two of these showed possible impairment. The rest were normal.This preliminary study suggests that hypoglycemia associated with neurological symptoms in the newborn period carries a poor prognosis with respect to permanent neurological damage. Asymptomatic hypoglycemia may have a relatively good prognosis.

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References

Haworth J, COODIN F, Finkel K, WEIDMAN M . Hypoglycemia associated with symptoms in the newborn period. Can Med Assoc J. 1963; 88:23-8. PMC: 1920909. View

NORVAL M . Blood sugar values in premature infants. J Pediatr. 1950; 36(2):177-84. DOI: 10.1016/s0022-3476(50)80203-2. View

WACHTER H . Hypoglycemia of the newborn infant. Mo Med. 1949; 46(12):837-42. View

LOWREY G, Graham B, TSAO M . Chemical homeostasis in the newborn infants of diabetic mothers. Pediatrics. 1954; 13(6):527-35. View

Brown R, Wallis P . Hypoglycaemia in the newborn infant. Lancet. 1963; 1(7294):1278-82. DOI: 10.1016/s0140-6736(63)91981-0. View

NELIGAN G, Robson E, Watson J . Hypoglycaemia in the newborn. A sequel of intrauterine malnutrition. Lancet. 1963; 1(7294):1282-4. DOI: 10.1016/s0140-6736(63)91982-2. View

HEBERDEN P, FRIEDLANDER F . Hypoglycaemic coma. Arch Dis Child. 1955; 30(152):372-6. PMC: 2011790. DOI: 10.1136/adc.30.152.372. View

Cornblath M, WYBREGT S, BAENS G, Klein R . SYMPTOMATIC NEONATAL HYPOGLYCEMIA. STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT. VIII. Pediatrics. 1964; 33:388-402. View

King E, GARNER R . The Colorimetric Determination of Glucose. J Clin Pathol. 1947; 1(1):30-3. PMC: 1023202. DOI: 10.1136/jcp.1.1.30. View

10.

Huggett A, Nixon D . Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. Lancet. 1957; 273(6991):368-70. DOI: 10.1016/s0140-6736(57)92595-3. View

11.

Cornblath M, ODELL G, LEVIN E . Symptomatic neonatal hypoglycemia associated with toxemia of pregnancy. J Pediatr. 1959; 55:545-62. DOI: 10.1016/s0022-3476(59)80239-0. View

12.

Farquhar J . The significance of hypoglycaemia in the newborn infant of the diabetic woman. Arch Dis Child. 1956; 31(157):203-11. PMC: 2011960. DOI: 10.1136/adc.31.157.203. View

13.

CONN J, SELTZER H . Spontaneous hypoglycemia. Am J Med. 1955; 19(3):460-78. DOI: 10.1016/0002-9343(55)90130-3. View

14.

KOMROWER G . Blood sugar levels in babies born of diabetic mothers. Arch Dis Child. 1954; 29(143):28-33. PMC: 2011552. DOI: 10.1136/adc.29.143.28. View

15.

KNOBLOCH H, PASAMANICK B . Syndrome of minimal cerebral damage in infancy. J Am Med Assoc. 1959; 170(12):1384-7. DOI: 10.1001/jama.1959.03010120020006. View

16.

Haworth J, COODIN F . Idiopathic spontaneous hypoglycemia in children. Report of seven cases and review of the literature. Pediatrics. 1960; 25:748-65. View

17.

BAENS G, Lundeen E, Cornblath M, Morrison M, HARR C . Studies of carbohydrate metabolism in the newborn infant. VI. Levels of glucose in blood in premature infants. Pediatrics. 1963; 31:580-9. View