Long-term Neurological Dysfunction and Neonatal Hypoglycaemia After Diabetic Pregnancy

Overview

Journal Arch Dis Child Fetal Neonatal Ed

Specialties Gynecology & Obstetrics
Pediatrics

Date 1999 Apr 9

PMID 10194986

Citations 37

Authors

E Stenninger

R Flink

B Eriksson

C Sahlen

Affiliations

Soon will be listed here.

Abstract

Aim: To determine if children born to mothers with diabetes mellitus during pregnancy, who subsequently developed neonatal hypoglycaemia, experienced long-term neurological dysfunction.

Methods: Thirteen children with, and 15 without, neonatal hypoglycaemia (blood glucose < 1.5 mmol/l) were randomly selected from a larger cohort and investigated at the age of 8 years. They were also compared with 28 age matched healthy controls.

Results: Children with neonatal hypoglycaemia had significantly more difficulties in a validated screening test for minimal brain dysfunction than controls and were also more often reported to be hyperactive, impulsive, and easily distracted. On psychological assessment, they had a lower total development score than normoglycaemic children born to diabetic mothers, and control children.

Conclusions: Neonatal hypoglycaemia in diabetic pregnancy was associated with long-term neurological dysfunction related to minimal brain dysfunction/deficits in attention, motor control, and perception.

Citing Articles

Neonatal Hypoglycemia and Neurodevelopmental Outcomes-An Updated Systematic Review and Meta-Analysis.

Diggikar S, Trif P, Mudura D, Prasath A, Mazela J, Ognean M Life (Basel). 2025; 14(12.

PMID: 39768326 PMC: 11677687. DOI: 10.3390/life14121618.

Maternal and neonatal outcomes following antenatal corticosteroids in pregnancies complicated by diabetes: a scoping review.

Atallah K, Moon S, Lee I, Pszczola R, Said J AJOG Glob Rep. 2024; 4(4):100416.

PMID: 39650740 PMC: 11625239. DOI: 10.1016/j.xagr.2024.100416.

Prenatal maternal diabetes, comorbidities, and risk for neurodevelopmental impairment in the first two years.

Nivins S, Giesbrecht G, Tomfohr-Madsen L, Lebel C Pediatr Res. 2024; .

PMID: 39390101 DOI: 10.1038/s41390-024-03620-7.

Neonatal hypoglycemia: pre-emptive monitoring and treatment may result in normal neurodevelopmental outcome.

Tam E Pediatr Res. 2023; 93(6):1456-1457.

PMID: 36739324 DOI: 10.1038/s41390-023-02511-7.

Executive function and behaviour problems in school-age children born at risk of neonatal hypoglycaemia.

Dai D, Franke N, McKinlay C, Wouldes T, Brown G, Shah R Dev Med Child Neurol. 2023; 65(9):1226-1237.

PMID: 36722028 PMC: 10387501. DOI: 10.1111/dmcn.15520.

References

Gillberg C, Rasmussen P . Perceptual, motor and attentional deficits in six-year-old children. Screening procedure in pre-school. Acta Paediatr Scand. 1982; 71(1):121-9. DOI: 10.1111/j.1651-2227.1982.tb09382.x. View

Haworth J, MCRAE K . THE NEUROLOGICAL AND DEVELOPMENTAL EFFECTS OF NEONATAL HYPOGLYCEMIA: A FOLLOW-UP OF 22 CASES. Can Med Assoc J. 1965; 92:861-5. PMC: 1928006. View

Gillberg C, Carlstrom G, Rasmussen P, Waldenstrom E . Perceptual, motor and attentional deficits in seven-year-old children. Neurological screening aspects. Acta Paediatr Scand. 1983; 72(1):119-24. DOI: 10.1111/j.1651-2227.1983.tb09675.x. View

Rasmussen P, Gillberg C . Perceptual, motor and attentional deficits in seven-year-old children. Paediatric aspects. Acta Paediatr Scand. 1983; 72(1):125-30. DOI: 10.1111/j.1651-2227.1983.tb09676.x. View

Persson B, GENTZ J . Follow-up of children of insulin-dependent and gestational diabetic mothers. Neuropsychological outcome. Acta Paediatr Scand. 1984; 73(3):349-58. DOI: 10.1111/j.1651-2227.1994.tb17747.x. View

Gerlini G, Arachi S, Gori M, Gloria F, Bonci E, Pachi A . Developmental aspects of the offspring of diabetic mothers. Acta Endocrinol Suppl (Copenh). 1986; 277:150-5. DOI: 10.1530/acta.0.111s0150. View

Petersen M, Pedersen S, Greisen G, Pedersen J . Early growth delay in diabetic pregnancy: relation to psychomotor development at age 4. Br Med J (Clin Res Ed). 1988; 296(6622):598-600. PMC: 2545234. DOI: 10.1136/bmj.296.6622.598. View

Koh T, Aynsley-Green A, Tarbit M, Eyre J . Neural dysfunction during hypoglycaemia. Arch Dis Child. 1988; 63(11):1353-8. PMC: 1779138. DOI: 10.1136/adc.63.11.1353. View

Koh T, Eyre J, Aynsley-Green A . Neonatal hypoglycaemia--the controversy regarding definition. Arch Dis Child. 1988; 63(11):1386-8. PMC: 1779139. DOI: 10.1136/adc.63.11.1386. View

10.

Lucas A, Morley R, Cole T . Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 1988; 297(6659):1304-8. PMC: 1834933. DOI: 10.1136/bmj.297.6659.1304. View

11.

Cornblath M, Schwartz R, Aynsley-Green A, Lloyd J . Hypoglycemia in infancy: the need for a rational definition. A Ciba Foundation discussion meeting. Pediatrics. 1990; 85(5):834-7. View

12.

Silverman B, Rizzo T, GREEN O, Cho N, Winter R, Ogata E . Long-term prospective evaluation of offspring of diabetic mothers. Diabetes. 1991; 40 Suppl 2:121-5. DOI: 10.2337/diab.40.2.s121. View

13.

Stenninger E, Schollin J, Aman J . Neonatal macrosomia and hypoglycaemia in children of mothers with insulin-treated gestational diabetes mellitus. Acta Paediatr Scand. 1991; 80(11):1014-8. DOI: 10.1111/j.1651-2227.1991.tb11776.x. View

14.

SELLS C, Robinson N, Brown Z, Knopp R . Long-term developmental follow-up of infants of diabetic mothers. J Pediatr. 1994; 125(1):S9-17. DOI: 10.1016/s0022-3476(94)70170-9. View

15.

Rizzo T, Ogata E, Dooley S, Metzger B, Cho N . Perinatal complications and cognitive development in 2- to 5-year-old children of diabetic mothers. Am J Obstet Gynecol. 1994; 171(3):706-13. DOI: 10.1016/0002-9378(94)90086-8. View

16.

Rizzo T, Dooley S, Metzger B, Cho N, Ogata E, Silverman B . Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers. Am J Obstet Gynecol. 1995; 173(6):1753-8. DOI: 10.1016/0002-9378(95)90422-0. View

17.

Kuperman S, Johnson B, Arndt S, Lindgren S, Wolraich M . Quantitative EEG differences in a nonclinical sample of children with ADHD and undifferentiated ADD. J Am Acad Child Adolesc Psychiatry. 1996; 35(8):1009-17. DOI: 10.1097/00004583-199608000-00011. View

18.

Bjorgaas M, Sand T, Gimse R . Quantitative EEG in type 1 diabetic children with and without episodes of severe hypoglycemia: a controlled, blind study. Acta Neurol Scand. 1996; 93(6):398-402. DOI: 10.1111/j.1600-0404.1996.tb00017.x. View

19.

Weintrob N, Karp M, Hod M . Short- and long-range complications in offspring of diabetic mothers. J Diabetes Complications. 1996; 10(5):294-301. DOI: 10.1016/1056-8727(95)00080-1. View

20.

Hod M, Rabinerson D, Kaplan B, Peled Y, Bar J, Shindel B . Perinatal complications following gestational diabetes mellitus how 'sweet' is ill?. Acta Obstet Gynecol Scand. 1996; 75(9):809-15. DOI: 10.3109/00016349609054708. View