INTESTINAL ABSORPTION OF BILE PIGMENTS. 3. THE ENTEROHEPATIC CIRCULATION OF UROBILINOGEN IN THE RAT

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1965 May 1

PMID 14276130

Citations 7

Authors

R Lester

R Schmid

Affiliations

Soon will be listed here.

Citing Articles

Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome.

Kipp Z, Badmus O, Stec D, Hall B, Hinds Jr T Metabolism. 2024; 163:156081.

PMID: 39580049 PMC: 11700773. DOI: 10.1016/j.metabol.2024.156081.

BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen.

Hall B, Levy S, Dufault-Thompson K, Arp G, Zhong A, Minabou Ndjite G Nat Microbiol. 2024; 9(1):173-184.

PMID: 38172624 PMC: 10769871. DOI: 10.1038/s41564-023-01549-x.

Bilirubin in the Liver-Gut Signaling Axis.

Hamoud A, Weaver L, Stec D, Hinds Jr T Trends Endocrinol Metab. 2018; 29(3):140-150.

PMID: 29409713 PMC: 5831340. DOI: 10.1016/j.tem.2018.01.002.

Absorption of bile pigments by the gall bladder.

Pstrpw J J Clin Invest. 1967; 46(12):2035-52.

PMID: 6074006 PMC: 292955. DOI: 10.1172/JCI105692.

Bile pigment excretion: a comparison of the biliary excretion of bilirubin and bilirubin derivatives.

Lester R, KLEIN P J Clin Invest. 1966; 45(12):1839-46.

PMID: 5927213 PMC: 292868. DOI: 10.1172/JCI105487.

References

Mann J, Koler R . The excretion in the bile of urobilinogen administered orally and parenterally. Gastroenterology. 1951; 17(3):400-5. View

GUSTAFSSON B, LANKE L . Bilirubin and urobilins in germfree, ex-germfree, and conventional rats. J Exp Med. 1960; 112:975-81. PMC: 2137325. DOI: 10.1084/jem.112.6.975. View

Watson C . The direct preparation of crystalline urobilin from bilirubin. J Biol Chem. 1953; 200(2):691-6. View

Lester R, Schmid R . ENTEROHEPATIC CIRCULATION OF UROBILINOGEN. Nature. 1964; 201:711-2. DOI: 10.1038/201711a0. View

Henry R, Fernandez A, Berkman S . STUDIES ON THE DETERMINATION OF BILE PIGMENTS. VI. UROBILINOGEN IN URINE AS UROBILINOGEN-ALDEHYDE. Clin Chem. 1964; 10:440-6. View

Schmid R . The identification of direct-reacting bilirubin as bilirubin glucuronide. J Biol Chem. 1957; 229(2):881-8. View

Schmid R, HAMMAKER L . METABOLISM AND DISPOSITION OF C14-BILIRUBIN IN CONGENITAL NONHEMOLYTIC JAUNDICE. J Clin Invest. 1963; 42:1720-34. PMC: 289456. DOI: 10.1172/JCI104858. View

KAHAN I, Csernay L, Varro V . Some experimental data on the intestinal absorption of urobilinoids. Clin Chim Acta. 1962; 7:392-7. DOI: 10.1016/0009-8981(62)90039-6. View

SBOROV V, JAY A, Watson C . The effect of aureomycin on urobilinogen formation and the fecal flora. J Lab Clin Med. 1951; 37(1):52-9. View

10.

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Lester R, Ostrow J, Schmid R . Enterohepatic circulation of bilirubin. Nature. 1961; 192:372. DOI: 10.1038/192372a0. View

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Martini G, PHEAR E, RUEBNER B, Sherlock S . The bacterial content of the small intestine in normal and cirrhotic subjects: relation to methionine toxicity. Clin Sci. 1957; 16(1):35-51. View

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Lester R, Schmid R . Intestinal absorption of bile pigments. I. The enterohepatic circulation of bilirubin in the rat. J Clin Invest. 1963; 42:736-46. PMC: 289340. DOI: 10.1172/JCI104766. View

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Schmid R, Axelrod J, HAMMAKER L, SWARM R . Congenital jaundice in rats, due to a defect in glucuronide formation. J Clin Invest. 1958; 37(8):1123-30. PMC: 1062779. DOI: 10.1172/JCI103702. View

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Watson C . Recent studies of the urobilin problem. J Clin Pathol. 1963; 16:1-11. PMC: 480477. DOI: 10.1136/jcp.16.1.1. View

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Bishop R . Bacterial flora of the small intestine of dogs and rats with intestinal blind loops. Br J Exp Pathol. 1963; 44:189-96. PMC: 2095188. View

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Lester R, Schmid R . Intestinal absorption of bile pigments. II. Bilirubin absorption in man. N Engl J Med. 1963; 269:178-82. DOI: 10.1056/NEJM196307252690402. View

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Ostrow J, HAMMAKER L, Schmid R . The preparation of crystalline bilirubin-C14. J Clin Invest. 1961; 40:1442-52. PMC: 292520. DOI: 10.1172/JCI104375. View