ENHANCEMENTS OF ANTIBIOTIC ACTIVITY OF COLICINE K AND ALTERATION OF SEROLOGICAL PROPERTIES OF COLICINE K AND ENDOTOXINS

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1965 Feb 1

PMID 14264271

Citations 4

Authors

H VANVUNAKIS

A Ruffilli

L Levine

Affiliations

Soon will be listed here.

Abstract

Hemoglobin, its chains, and myoglobin enhance the antibiotic activity of colicine K. These proteins also interact with colicine K and other O antigens to alter their serological activity. The hemoglobin proteins did not alter the serological activities of three Pneumococcus polysaccharides or T4 bacteriophage DNA antigens but did alter the antigenic activity of fetuin. Interaction of hemoglobin and colicine K resulted in a retardation of colicine K antibiotic moiety as measured by gel filtration but did not affect the gel filtration properties of the lipopolysaccharide moiety.

Citing Articles

Alteration and restoration of endotoxin activity after complexing with plasma proteins.

Rudbach J, Johnson A J Bacteriol. 1966; 92(4):892-8.

PMID: 5926756 PMC: 276350. DOI: 10.1128/jb.92.4.892-898.1966.

Colicine K. VII. The transfer to type K colicinogeny to Shigella sonnei.

HINSDILL R, GOEBEL W J Exp Med. 1966; 123(5):881-95.

PMID: 5328216 PMC: 2138165. DOI: 10.1084/jem.123.5.881.

In vitro and in vivo characterization of pyocin.

Higerd T, Baechler C, Berk R J Bacteriol. 1967; 93(6):1976-86.

PMID: 4960899 PMC: 276718. DOI: 10.1128/jb.93.6.1976-1986.1967.

Colicinogeny and related phenomena.

Hardy K Bacteriol Rev. 1975; 39(4):464-515.

PMID: 1108869 PMC: 408342. DOI: 10.1128/br.39.4.464-515.1975.

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