IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS; A SEARCH FOR ANTIBODY-ABSORBING DEPOTS OF ALLERGEN

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1963 Dec 1

PMID 14112263

Citations 11

Authors

J R BATTISTO

M W Chase

Affiliations

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Abstract

Guinea pigs fed picryl chloride to induce specific immunologic unresponsiveness cleared small amounts of venously infused antipicryl antibody at a rate equal to that of normal guinea pigs. Catabolism of passively administered picryl-specific antibody did not alter the unresponsive state of picryl chloride-fed guinea pigs or the responsive state of normal guinea pigs. Lymphoid cells of picryl chloride immunized guinea pigs produced equal amounts of picryl-specific antibody in picryl chloride-fed and normal animals. Allergen-fed guinea pigs remained unresponsive to attempted sensitization with the allergen in excess of 10 months after the final feeding, though some became feebly sensitive between 9 and 11 months. Second attempts to make unresponsive animals hypersensitive were unsuccessful. White blood cells of guinea pigs unresponsive to picryl chloride were unable to transfer delayed-type hypersensitivity for picryl chloride to normal recipients yet readily transferred tuberculin hypersensitivity.

Citing Articles

THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. II. THE PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO MULTIPLE INJECTIONS OF ANTIGEN BEGUN AT BIRTH.

Rowley D, Fitch F J Exp Med. 1965; 121:683-95.

PMID: 14278225 PMC: 2137998. DOI: 10.1084/jem.121.5.683.

INDUCED UNRESPONSIVENESS TO SIMPLE ALLERGENIC CHEMICALS. II. INDEPENDENCE OF DELAYED-TYPE HYPERSENSITIVITY AND FORMATION OF CIRCULATING ANTIBODY.

BATTISTO J, Chase M J Exp Med. 1965; 121:591-606.

PMID: 14276779 PMC: 2137987. DOI: 10.1084/jem.121.4.591.

HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT.

Rowley D, Fitch F J Exp Med. 1964; 120:987-1005.

PMID: 14238938 PMC: 2137793. DOI: 10.1084/jem.120.6.987.

CORYNEBACTERIAL PSEUDOTUBERCULOSIS IN MICE. II. ACTIVATION OF NATURAL AND EXPERIMENTAL LATENT INFECTIONS.

FAUVE R, PIERCE-CHASE C, Dubos R J Exp Med. 1964; 120:283-304.

PMID: 14208250 PMC: 2137733. DOI: 10.1084/jem.120.2.283.

Immunological tolerance to microbial antigens. II. Suppressed antibody plaque formation to Shigella antigen by spleen cells from tolerant mice.

Friedman H J Bacteriol. 1966; 92(4):820-7.

PMID: 5926751 PMC: 276340. DOI: 10.1128/jb.92.4.820-827.1966.

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