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Cytochemical and Electron Microscopic Studies of Rat Liver with Reduced Capacity to Transport Conjugated Bilirubin

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1962 Mar 1
PMID 13899761
Citations 19
Authors
S Goldfischer
I M Arias
E Essner
A B NOVIKOFF
Affiliations
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Abstract

ALTHOUGH THE LIVERS OF RATS TREATED WITH AGENTS KNOWN TO SUPPRESS BILIRUBIN TRANSPORT APPEARED RELATIVELY NORMAL ON ROUTINE HISTOLOGICAL SECTIONS, CYTOCHEMICAL AND ELECTRON MICROSCOPIC PREPARATIONS REVEALED MARKED CHANGES IN: (a) levels of alkaline phosphatase and apparent ATPase activities of the cell membrane at the sinusoids, bile canaliculi, and between adjacent cells; (b) morphology of the bile canaliculi such as dilatation, fragmentation, vesiculation and reduced numbers of microvilli; (c) the number of lysosomes and their distribution within the cell. Similar changes in the cytochemistry of the liver cell were induced by extrahepatic obstruction.

Citing Articles

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MUELLER M, Kappas A J Clin Invest. 1964; 43:1905-14.

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HEPATIC PARENCHYMAL CELL ALTERATIONS AFTER LONG-TERM CARBON TETRACHLORIDE ADMINISTRATION. A LIGHT AND ELECTRON MICROSCOPIC STUDY.

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ELECTRON MICROSCOPY IN THE EXCRETORY PATHWAYS IN THE LIVER IN ALPHA-NAPHTHYL ISOTHIOCYANATE INTOXICATION. A STUDY OF INTRAHEPATIC CHOLESTASIS.

Steiner J, Phillips M, BAGLIO C Am J Pathol. 1963; 43:677-96.

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Studies of hepatic excretory function. The effect of 17alpha-ethyl-19-nortestosterone on sulfobromophthalein sodium (BSP) metabolism in man.

SCHERB J, Kirschner M, Arias I J Clin Invest. 1963; 42:404-8.

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References
1.
Essner E, NOVIKOFF A . Localization of acid phosphatase activity in hepatic lysosomes by means of electron microscopy. J Biophys Biochem Cytol. 1961; 9:773-84. PMC: 2225049. DOI: 10.1083/jcb.9.4.773. View
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Schaffner F, Popper H, Perez V . Changes in bile canaliculi produced by norethandrolone: electron microscopic study of human and rat liver. J Lab Clin Med. 1960; 56:623-8. View
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NOVIKOFF A, Drucker J, Shin W, Goldfischer S . Further studies of the apparent adenosinetriphosphatase activity of cell membranes in formol-calcium-fixed tissues. J Histochem Cytochem. 1961; 9:434-51. DOI: 10.1177/9.4.434. View
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NOVIKOFF A, Goldfischer S, Essner E . The importance of fixation in a cytochemical method for the Golgi apparatus. J Histochem Cytochem. 1961; 9:459-60. DOI: 10.1177/9.4.459. View
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NOVIKOFF A, Essner E . The liver cell. Some new approaches to its study. Am J Med. 1960; 29:102-31. DOI: 10.1016/0002-9343(60)90011-5. View